| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| 5g |
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| 10g |
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Purity: ≥98%
Penicillin G sodium, the sodium salt of penicillin G, is a typical penicillin derivative and β-lactam antibiotic commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
| Targets |
β-lactam
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|---|---|
| ln Vitro |
The Penicillin G sodium salt-TEM-1 system's ultraviolet-visible (UV-Vis) absorption spectrum differs significantly from that of Penicillin G sodium salt and TEM-1 β-lactamase, suggesting the formation of new complexes between the two enzymes. As the concentration of Penicillin G sodium salt increases, the UV-Vis absorption of TEM-1 β-lactamase increases and there is a slight red-shift, suggesting that the interaction between Penicillin G sodium salt and TEM-1 β-lactamase causes minor conformational changes in TEM-1 β-lactamase[1].
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| ln Vivo |
According to the logistic regression model, the pigs treated with Penicillin G sodium salt had a 1.6-fold lower probability of a positive swab than the control group (P<0.05). Compared to having zero colonies per plate, the control group's risk of a swab containing 10 to 99 colonies was 2.3 times higher than that of the pigs given Penicillin G sodium salt treatment (P=0.022)[2].
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| Enzyme Assay |
TEM-1β-lactamase solution (5×10-6 M) is mixed with solutions of cefalexin, cefoxitin, and Penicillin G sodium salt at different concentrations at 278 K. The three antibiotics are progressively added to a concentration of 0 to 25×10-6 M. Ultraviolet-visible (UV-Vis) absorption spectra are recorded on a spectrophotometer with a 2 nm slit and a 400 nm/min scanning speed after mixing and interacting for 2 minutes, with 0.02 M phosphate buffer (pH 7.0) serving as a reference[1].
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| Animal Protocol |
For this study, a randomized complete block design with two replicates is employed. With 16 pens and 28 pigs per pen, a replicate has 448 pigs total. Pigs are also sorted by weight, with animals grouped together in blocks according to visual observation of similar weight. Through the use of a formal randomization procedure, two treatments are assigned at random within each block of two adjacent pens. The two treatment groups are Treated (sodium salt of penicillin G) and Control (no treatment). Drinking water containing Penicillin G sodium salt is given for five days during two treatment sessions. Day 1 (the day the pigs are moved into the nursery barns) marks the start of the first treatment period, which ends on Day 5. Day 21 marks the start of the second treatment phase, which lasts until Day 25. There is no treatment given to the Control group[2].
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| References |
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| Molecular Formula |
C16H17N2NAO4S
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|---|---|
| Molecular Weight |
356.3720
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| Exact Mass |
372.05
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| Elemental Analysis |
C, 53.93; H, 4.81; N, 7.86; Na, 6.45; O, 17.96; S, 9.00
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| CAS # |
69-57-8
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| Related CAS # |
Penicillin G potassium;113-98-4;Penicillin G procaine hydrate;6130-64-9;Penicillin G benzathine;1538-09-6;Penicillin G benzathine tetrahydrate;41372-02-5;Penicillin G;61-33-6
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| Appearance |
Solid powder
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| SMILES |
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)[O-].[Na+]
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| InChi Key |
FCPVYOBCFFNJFS-LQDWTQKMSA-M
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| InChi Code |
InChI=1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
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| Chemical Name |
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((2-phenylacetyl)amino)- (2S,5R,6R)-, sodium salt (1:1)
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| Synonyms |
Benzylpenicillin sodium salt; Penicillin G sodium salt; Monosodium benzylpenicillin; Mycofarm; Novocillin; NSC 402815; OK 431; Pen-A-Brasive;
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product is not stable in solution, please use freshly prepared working solution for optimal results. (2). Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 71~100 mg/mL ( 199.23~280.61 mM )
Water : 71~125 mg/mL(~350.76 mM) Ethanol : ~1 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.02 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.02 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.02 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.5 mg/mL (7.02 mM) Solubility in Formulation 5: 100 mg/mL (280.61 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8061 mL | 14.0304 mL | 28.0607 mL | |
| 5 mM | 0.5612 mL | 2.8061 mL | 5.6121 mL | |
| 10 mM | 0.2806 mL | 1.4030 mL | 2.8061 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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