| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| 1g |
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| Other Sizes |
|
| ln Vitro |
2-Phenylethanol activates preservatives in soap and additives for cigarettes [1]. 2. Phenylethyl alcohol inhibits the growth of dyes that are Gram-negative [1].
|
|---|---|
| ln Vivo |
In mice, 2-phenylethanol (5%; breathed) decreases depressive-like behavior and enhances anxiety-like behavior [3].
|
| Animal Protocol |
Animal/Disease Models: 11weeks old male mice (C57BL/6) [3]
Doses: 5% (v/v) Route of Administration: inhalation; Experimental Results:It exerts an antidepressant-like effect, but may increase anxiety-like behaviors. |
| References |
[1]. Y.-J. Zhu et al. Antityrosinase and antimicrobial activities of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid. Food Chemistry 124 (2011) 298-302.
[2]. M M W Etschmann, et al. Biotechnological production of 2-phenylethanol. Appl Microbiol Biotechnol. 2002 Jun;59(1):1-8. [3]. Hiroshi Ueno, et al. Anti-depressive-like effect of 2-phenylethanol inhalation in mice. Biomed Pharmacother. 2019 Mar:111:1499-1506. |
| Molecular Formula |
C8H10O
|
|---|---|
| Molecular Weight |
122.17
|
| Exact Mass |
122.0732
|
| CAS # |
60-12-8
|
| Related CAS # |
2-Phenylethanol-d4;107473-33-6;2-Phenylethanol-d9;42950-74-3;2-Phenylethanol-d5;35845-63-7
|
| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
|
| SMILES |
O([H])C([H])([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H]
|
| Synonyms |
Phenylethyl alcohol NSC 406252 NSC 406252 NSC406252 NSC-406252
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| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~20 mg/mL (~163.72 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (409.30 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.1853 mL | 40.9266 mL | 81.8532 mL | |
| 5 mM | 1.6371 mL | 8.1853 mL | 16.3706 mL | |
| 10 mM | 0.8185 mL | 4.0927 mL | 8.1853 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT02624362 | ENROLLING BY INVITATION | Behavioral: Therapeutic Suggestion Behavioral: Asthmogenic Suggestion Other: Phenylethyl Alcohol odor |
Asthma | Universitaire Ziekenhuizen KU Leuven | 2015-08 | Not Applicable |
| NCT05908318 | NOT YET RECRUITING | Behavioral: olfactory training | Postoperative Delirium Preoperative Olfactory Training |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 2023-07 | Not Applicable |
| NCT06290219 | NOT YET RECRUITING | Combination Product: platelet-rich plasma combined with hyaluronic acid Drug: Zinc Gluconate 10 MG Oral Tablet Device: 4 bottles of phenyl ethyl alcohol, lemon, eucalyptus, and clove oil |
Effect of Drug Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis) | Taichung Veterans General Hospital | 2024-03-20 | Phase 3 |
| NCT01380691 | COMPLETEDWITH RESULTS | Drug: LY2216684 Drug: Placebo-matching LY2216684 Drug: Placebo-matching alcoholic beverage Drug: Alcoholic beverage |
Major Depressive Disorder | Eli Lilly and Company | 2011-06 | Phase 1 |
| NCT06066307 | RECRUITING | Other: Olfactory training | Loss of Smell Olfactory Disorder | Leigh Sowerby | 2023-09-25 | Phase 4 |
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