Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Purity: ≥98%
Pinocembrin [(+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone] is a naturally occuring flavonoid widely found in damiana, honey, fingerroot, and propolis with potent antioxidant, antimicrobial, anti-inflammatory and gastrointestinal protective effects. It acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent.
ln Vitro |
Pinocembrin (5, 10, 25, 50, 100, or 200 µM, 24 hours) dramatically lowers RBL-2H3 cell viability[1].
At 25 or 50 µM, pinocembrin decreases iNOS, PGE-2, and COX-2 levels, raises p38-Mapk and IкB-α, and prevents IкB-α phosphorylation[1]. |
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Cell Assay |
Cell Line: RBL-2H3 cells
Concentration: 5, 10, 25, 50, 100 or 200 µM Incubation Time: 24 hours Result:50% less cells viable at concentrations of ≥ 100 µM. demonstrated 75% cell viability at reduced dosages. |
References |
[2]. Chen Y, Wang K. Pinocembrin Protects Against Dextran Sulfate Sodium-Induced Rats Colitis by Ameliorating Inflammation, Improving Barrier Function and Modulating Gut Microbiota. Front Physiol. 2019 Jul 19;10:908. |
Molecular Formula |
C15H12O4
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Molecular Weight |
256.257
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Exact Mass |
256.0736
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Elemental Analysis |
C, 70.31; H, 4.72; O, 24.97
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CAS # |
480-39-7
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Related CAS # |
480-39-7
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Appearance |
Solid powder
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SMILES |
O=C1C[C@@H](C2=CC=CC=C2)OC3=CC(O)=CC(O)=C13
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InChi Key |
URFCJEUYXNAHFI-ZDUSSCGKSA-N
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InChi Code |
InChI=1S/C15H12O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-7,13,16-17H,8H2/t13-/m0/s1
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Chemical Name |
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)-
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Synonyms |
Pinocembrin(+)-Pinocoembrin Dihydrochrysin Galangin flavanone
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : 51~83.33 mg/mL (199.02~325.19 mM)
Ethanol : ~51 mg/mL |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (8.12 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (8.12 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (8.12 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.08 mg/mL (8.12 mM) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.9023 mL | 19.5114 mL | 39.0229 mL | |
5 mM | 0.7805 mL | 3.9023 mL | 7.8046 mL | |
10 mM | 0.3902 mL | 1.9511 mL | 3.9023 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.