Size | Price | Stock | Qty |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Plumbagin(2-Methyljuglone) is a naturally occurring naphthoquinone isolated from Plumbago zeylanica L with antimalarial and antiproliferative activities; acting as an inhibitor of human cytochrome P450 enzymes.
ln Vitro |
In a dose-dependent manner, plumbabin (0, 5, 10, and 15 μM) activates adapters of AIDS lines, including DU145, CWR22rv1, and LNCaP[1]. (5, 20 μM) greatly reduces PC3, DU145, and CWR22rv1 cell apoptosis studies [1].
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ln Vivo |
Plumbagin (2 mg/kg, ip, 5 days per week for 11 weeks) is a tumor suppressor of growth in athymic nude mice [1]. Plumbagin (2 mg/kg, ip, 5 days per week for 11 weeks) inhibits the expression of PKCε, inhibits JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice [ 1].
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Cell Assay |
Apoptosis Analysis[1]
Cell Types: DU145, CWR22rv1, LNCaP and RWPE-1 Cell Tested Concentrations: 0, 5, 10, and 15 μM Incubation Duration: 24 hrs (hours) Experimental Results: dose-dependent induction of apoptosis of DU145 and CWR22rv1. and LNCaP, but had no effect on RWPE-1 cells at concentrations up to 20 μM. |
Animal Protocol |
Animal/Disease Models: Male athymic nude mice DU145 cells [1]
Doses: 2 mg/kg Route of Administration: intraperitoneal (ip) injection 3 days after cell implantation, 5 days a week. Experimental Results: Delayed tumor growth by 3 weeks and diminished tumor weight and volume in mice. |
References |
[1]. Aziz MH, et al. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008 Nov 1;68(21):9024-32.
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Molecular Formula |
C11H8O3
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Molecular Weight |
188.1794
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CAS # |
481-42-5
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
O([H])C1=C([H])C([H])=C([H])C2C(C(C([H])([H])[H])=C([H])C(C=21)=O)=O
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ≥ 150 mg/mL (~797.11 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (11.05 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (11.05 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.3141 mL | 26.5703 mL | 53.1406 mL | |
5 mM | 1.0628 mL | 5.3141 mL | 10.6281 mL | |
10 mM | 0.5314 mL | 2.6570 mL | 5.3141 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.