| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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Pluripotin HCl, the hydrochloride salt of Pluripotin, is a novel and potent activator of murine embryonic stem (ES). Pluripotin (also known as SC1; SC-1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP as well as a sustainer of mES self-renewal.
| ln Vitro |
Pluripotin (SC-1) has IC50s of 0.005, 1.4, 2.2, 0.5, 2.5, 3.3, and 10.0 µM, respectively, and inhibits Abl1, p70S6K, PLK2, RSK1, RSK2, RSK3, and RSK4. Pluripotin (SC-1) inhibits the development of seven cell lines used in colon tumors. Following a five-day exposure to 0.1 µM SC-1, the vitality and quantity of cells in each of the seven colon tumor lines are assessed. The number of cells has decreased statistically significantly, but the viability is still around 95%[2].
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| ln Vivo |
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| Animal Protocol |
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| References |
| Molecular Formula |
C27H25F3N8O2
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|---|---|
| Molecular Weight |
550.53
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| Exact Mass |
550.205
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| Elemental Analysis |
C, 58.90; H, 4.58; F, 10.35; N, 20.35; O, 5.81
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| CAS # |
839707-37-8
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| PubChem CID |
12003241
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| Appearance |
White to off-white solid powder
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| Density |
1.4±0.1 g/cm3
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| Index of Refraction |
1.662
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| LogP |
2.37
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
9
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
40
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| Complexity |
925
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| Defined Atom Stereocenter Count |
0
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| SMILES |
0
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| Synonyms |
SC-1; SC 1; SC1; Pluripotin
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~25 mg/mL (~45.41 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.54 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.54 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8164 mL | 9.0822 mL | 18.1643 mL | |
| 5 mM | 0.3633 mL | 1.8164 mL | 3.6329 mL | |
| 10 mM | 0.1816 mL | 0.9082 mL | 1.8164 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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