| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| 10mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| Other Sizes |
|
| ln Vitro |
Pogostone exhibits an inhibitory effect on HCT116 cells, as demonstrated by its IC50 value of 18.7±1.93 μg/mL. Its cytotoxicity is significantly reduced when applied to normal human embryonic kidney cells 293A and endothelial cells HUVEC, with IC50 values of 95.13±19.44 μg/mL and 112±20.77 μg, respectively) milliliter) [1].
|
|---|---|
| ln Vivo |
In vivo antibacterial efficacy against Escherichia coli (E. coli) and MRSA is demonstrated by pogostone (intraperitoneal injection; 25, 50, and 100 mg/kg). 90% protection against E. Col infection was given at dosages of 50 and 100 mg/kg and 60% protection at 25 mg/kg, however mice infected with MRSA infection only received 60% protection. and 50% at 100 and 50 mg/kg dosages, respectively[2].
|
| References |
[1]. Peng F, et al. In vitro and in vivo antibacterial activity of Pogostone.Chin Med J (Engl). 2014;127(23):4001-5.
[2]. Cao ZX, et al. Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells.J Ethnopharmacol. 2017 Apr 18;202:20-27. |
| Molecular Formula |
C12H16O4
|
|---|---|
| Molecular Weight |
224.2530
|
| Exact Mass |
224.10
|
| Elemental Analysis |
C, 64.27; H, 7.19; O, 28.54
|
| CAS # |
23800-56-8
|
| Appearance |
Solid powder
|
| SMILES |
CC1=CC(=C(C(=O)O1)C(=O)CCC(C)C)O
|
| InChi Key |
AJFJTORMMHWKFW-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C12H16O4/c1-7(2)4-5-9(13)11-10(14)6-8(3)16-12(11)15/h6-7,14H,4-5H2,1-3H3
|
| Chemical Name |
4-hydroxy-6-methyl-3-(4-methylpentanoyl)pyran-2-one
|
| Synonyms |
Pogostone
|
| HS Tariff Code |
Solid powder
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~445.93 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (11.15 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (11.15 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (11.15 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4593 mL | 22.2965 mL | 44.5931 mL | |
| 5 mM | 0.8919 mL | 4.4593 mL | 8.9186 mL | |
| 10 mM | 0.4459 mL | 2.2297 mL | 4.4593 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
