| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| ln Vitro |
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors. The IC50 values for inhibition of LPA-induced calcium mobilization are 10 μM, 5.5 μM, and 3.1 μM, respectively. At a concentration of 10 μM, tetradecyl phosphonate activated a peroxisome proliferator-activated receptor gamma reporter construct 4-fold compared to control and partially inhibited autotaxin with an IC50 value of approximately 3 μM. Lysophosphatidic acid (LPA), also known as autotaxin (ATX), is a lipid signaling molecule formed by the hydrolysis of lysophosphatidylcholine by lysophospholipase D. LPA signals through four different G protein-coupled receptors, named LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7, and LPA4/GPR23. It has been reported that LPA is involved in the activation of peroxisome proliferator-activated receptor γ (PPARγ).
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| References |
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| Molecular Formula |
C14H31O3P
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|---|---|
| Molecular Weight |
278.37
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| CAS # |
4671-75-4
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| SMILES |
P(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(=O)(O[H])O[H]
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| Synonyms |
TDPA; Tetradecyl phosphonate
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5923 mL | 17.9617 mL | 35.9234 mL | |
| 5 mM | 0.7185 mL | 3.5923 mL | 7.1847 mL | |
| 10 mM | 0.3592 mL | 1.7962 mL | 3.5923 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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