| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| Other Sizes |
|
| Targets |
CSE
|
|---|---|
| ln Vitro |
On H2O2-induced H9c2 cells, norswertianolin (3.125~50 μM; H9c2 cells) exhibits protective properties. In H9c2 cells, norswertianolin dramatically raises HO-1 and GCLC transcription levels[1]. The CSE protein level is increased by norswertianolin (0~150 μM) at high concentrations in HepG2 cells[2].
|
| ln Vivo |
Norswertianolin increases CSE/H2S production (4.4 mg/kg/day; s.c.; 1 week)[2]. Acute I/R renal tubular injury is lessened by the use of norswertianolin. The DHE fluorescence intensity of norswertianolin also lowers I/R-stimulated ROS. Inhibiting vascular remodeling, reducing inflammation, and having anti-hypertensive effects are the actions of norswertianolin [2].
|
| Animal Protocol |
Animal/Disease Models: Male Sprague Dawley rats (10~12 weeks)[2]
Doses: 4.4 mg/kg/day Route of Administration: S.c. Experimental Results: Improved CSE/H2S production. |
| References |
|
| Additional Infomation |
Norswertianolin is a beta-D-glucoside that is bellidin in which a beta-D-glucopyranosyl residue is attached at position O-8. A natural product found particularly in Gentiana campestris and Gentiana germanica. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a metabolite. It is a member of xanthones and a beta-D-glucoside. It is functionally related to a bellidin.
Norswertianolin has been reported in Swertia macrosperma, Gentianella nitida, and other organisms with data available. |
| Molecular Formula |
C19H18O11
|
|---|---|
| Molecular Weight |
422.34
|
| Exact Mass |
422.084
|
| CAS # |
54954-12-0
|
| PubChem CID |
5281659
|
| Appearance |
White to light yellow solid
|
| Density |
1.8±0.1 g/cm3
|
| Boiling Point |
833.7±65.0 °C at 760 mmHg
|
| Flash Point |
300.4±27.8 °C
|
| Vapour Pressure |
0.0±3.2 mmHg at 25°C
|
| Index of Refraction |
1.758
|
| LogP |
-1.66
|
| Hydrogen Bond Donor Count |
7
|
| Hydrogen Bond Acceptor Count |
11
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
30
|
| Complexity |
632
|
| Defined Atom Stereocenter Count |
5
|
| SMILES |
O1[C@]([H])([C@@]([H])([C@]([H])([C@@]([H])([C@@]1([H])C([H])([H])O[H])O[H])O[H])O[H])OC1C([H])=C([H])C(=C2C=1C(C1=C(C([H])=C(C([H])=C1O2)O[H])O[H])=O)O[H]
|
| InChi Key |
MYWLBRTZOYHDOU-FJMCMGCSSA-N
|
| InChi Code |
InChI=1S/C19H18O11/c20-5-11-14(24)16(26)17(27)19(30-11)29-9-2-1-7(22)18-13(9)15(25)12-8(23)3-6(21)4-10(12)28-18/h1-4,11,14,16-17,19-24,26-27H,5H2/t11-,14-,16+,17-,19-/m1/s1
|
| Chemical Name |
1,3,5-trihydroxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one
|
| Synonyms |
Norswertianolin
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 25 mg/mL (59.19 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.92 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (5.92 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3678 mL | 11.8388 mL | 23.6776 mL | |
| 5 mM | 0.4736 mL | 2.3678 mL | 4.7355 mL | |
| 10 mM | 0.2368 mL | 1.1839 mL | 2.3678 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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