Size | Price | Stock | Qty |
---|---|---|---|
5mg |
|
||
10mg |
|
||
50mg |
|
||
100mg |
|
||
Other Sizes |
|
ln Vitro |
While actual α-syn aggregates in human brain sections are difficult for MODAG-001 to engage, it exhibits significant binding affinity to recombinant human α-syn aggregates[2].
|
---|---|
References |
[1]. Bousiges O, et al. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. Int J Mol Sci. 2022 Jun 7;23(12):6371.
[2]. Bian J, et al. Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands. Eur J Med Chem. 2021 Dec 15;226:113887. [3]. Akasaka T, et al. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorg Med Chem Lett. 2022 May 15;64:128679. |
Molecular Formula |
C16H15BRN4
|
---|---|
Molecular Weight |
343.22
|
CAS # |
2648041-72-7
|
Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
|
SMILES |
C1(N(C)C)=CC=C(C2C=C(C3C=CN=C(Br)C=3)NN=2)C=C1
|
HS Tariff Code |
2934.99.9001
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
DMSO: 25 mg/mL (72.84 mM)
Methanol: 4.9 mg/mL (14.28 mM) |
---|---|
Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 4.17 mg/mL (12.15 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 41.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.9136 mL | 14.5679 mL | 29.1358 mL | |
5 mM | 0.5827 mL | 2.9136 mL | 5.8272 mL | |
10 mM | 0.2914 mL | 1.4568 mL | 2.9136 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.