| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| Targets |
Ki: 40 nM (PI5P4Kα) and 30 nM (PI5P4Kβ)[1]
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|---|---|
| ln Vitro |
CC260 (20 μM) reduces S6K phosphorylation (Thr-389) by mTORC1 but increases Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 in cultured C2C12 myotubes[1]. Acetyl-CoA carboxylase (ACC) phosphorylation is greatly increased by CC260 (2.5 μM, 5 μM, 10 μM, and 20 μM) in a dose-dependent manner[1]. Treatment with CC260 decreases the ability of BT474 cells to withstand serum starvation; however, this ability can be restored by expressing the refractory mutant PI5P4Kβ[1]. Treatment with CC260 increases the generation of glycolytic ATP in BT474 cells[1].
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| References |
| Molecular Formula |
C24H29CL2N5O2
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|---|---|
| Molecular Weight |
490.43
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| Exact Mass |
489.169
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| CAS # |
2411088-26-9
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| PubChem CID |
146347307
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| Appearance |
Off-white to gray solid powder
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| LogP |
6.5
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
5
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| Heavy Atom Count |
33
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| Complexity |
678
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| Defined Atom Stereocenter Count |
1
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| SMILES |
N1=C2C(N(C)C(=O)[C@@H](CC3CCCC3)N2C2CCCC2)=CN=C1NC1=CC(Cl)=C(O)C(Cl)=C1
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| InChi Key |
AEZJZTFWCDAUDF-LJQANCHMSA-N
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| InChi Code |
InChI=1S/C24H29Cl2N5O2/c1-30-20-13-27-24(28-15-11-17(25)21(32)18(26)12-15)29-22(20)31(16-8-4-5-9-16)19(23(30)33)10-14-6-2-3-7-14/h11-14,16,19,32H,2-10H2,1H3,(H,27,28,29)/t19-/m1/s1
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| Chemical Name |
(7R)-8-cyclopentyl-7-(cyclopentylmethyl)-2-(3,5-dichloro-4-hydroxyanilino)-5-methyl-7H-pteridin-6-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 160 mg/mL (326.24 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 4 mg/mL (8.16 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 40.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 4 mg/mL (8.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 40.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0390 mL | 10.1951 mL | 20.3903 mL | |
| 5 mM | 0.4078 mL | 2.0390 mL | 4.0781 mL | |
| 10 mM | 0.2039 mL | 1.0195 mL | 2.0390 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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