| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| Targets |
OSBPL7[1] ABCA1[1]
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|---|---|
| ln Vitro |
In human podocytes cultivated in vitro, OSBPL7-IN-1 (compound G or Cpd G; 1-10 µM) increases the plasma membrane ATP-binding cassette transporter (ABCA1) and dramatically increases ABCA1-dependent cholesterol efflux[1].
|
| ln Vivo |
In animal models of proteinuric kidney illness, therapy with OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) normalizes proteinuria and avoids the deterioration of renal function[1].
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| Animal Protocol |
Animal/Disease Models: Female balb/c (Bagg ALBino) mouse induced by Adriamycin (ADR)[1]
Doses: 100 mg/kg Route of Administration: Oral gavage; daily; for 28 days Experimental Results: Normalized proteinuria, and Dramatically decreased renal fibrosis and renal functional decline. |
| References |
[1]. Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12(1):4662.
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| Molecular Formula |
C20H19CL2F3N2O3
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|---|---|
| Molecular Weight |
463.28
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| CAS # |
1269826-44-9
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| Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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| SMILES |
C1=NC(OCC(F)(F)F)=C(C2=CC=C(Cl)C(Cl)=C2)C=C1C(N[C@@H]1CCCC[C@H]1O)=O
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 125 mg/mL (269.82 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.49 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1585 mL | 10.7926 mL | 21.5852 mL | |
| 5 mM | 0.4317 mL | 2.1585 mL | 4.3170 mL | |
| 10 mM | 0.2159 mL | 1.0793 mL | 2.1585 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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