Size | Price | Stock | Qty |
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5mg |
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10mg |
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50mg |
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100mg |
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Other Sizes |
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ln Vitro |
With a GI50 of 19.0 μM, COQ7-IN-1 (Compound 8; 0-30 μM; for 4 days) inhibits the growth of WI-38 cells. With a GI50 of 9.0±1.1 μM, COQ7-IN-1 weakly inhibits the growth of C3A cells. By reducing oxidative stress or blocking aerobic respiration, COQ7-IN-1 does not reduce the survival of C3A cells[1]. Demethoxy-UQ (DMQ) is changed to demethyl-UQ (DMeQ) by COQ7, which is subsequently changed to UQ by COQ3. Lack of COQ7 prevents cells from producing UQ, which leads to the accumulation of DMQ. For COQ7-IN-1 (10 μM; for 2 days) cultured with HeLa cells, the DMQ10 and UQ10 contents in each culture well are 13.2 and 12.2 ng/well, respectively. In HeLa cells, the DMQ10 content of COQ7-IN-1 is 52.0%[1].
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Cell Assay |
Cell Viability Assay[1]
Cell Types: WI-38 cells Tested Concentrations: 0-30 μM Incubation Duration: 4 days Experimental Results: The concentration that caused 50% cell growth inhibition (GI50 ) was 19.0 μM. |
References |
[1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182.
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Molecular Formula |
C14H10CLN3O
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Molecular Weight |
271.70
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CAS # |
2579696-72-1
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
C1C(C2=CC=CC=C2)=NN(C2N=CC(=CC=2)Cl)C=1O
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: 100 mg/mL (368.05 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (7.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.6805 mL | 18.4026 mL | 36.8053 mL | |
5 mM | 0.7361 mL | 3.6805 mL | 7.3611 mL | |
10 mM | 0.3681 mL | 1.8403 mL | 3.6805 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.