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| Other Sizes |
| ln Vitro |
For research in the field of life sciences, perylene is a biochemical reagent that can be utilized as an organic compound or biological material.
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| ADME/Pharmacokinetics |
Metabolism / Metabolites
An investigation of the metabolism of the weak carcinogen, benz(a)anthracene, was compared to that of a group of noncarcinogenic hydrocarbons including benzo(e)pyrene, pyrene, phenanthrene, coronene, triphenylene, and perylene. Male Sprague-Dawley rats were administered sc 0.4 uM doses of these polynuclear aromatic hydrocarbons. Results from HPLC and MS demonstrated that benz(a)anthracene was observed to undergo bioalkylation and biooxidation reactions in rat sc tissue. The other compounds tested did not demonstrate detectable bioalkylation reactions in vivo. These results were consistent with the carcinogenic activity of benz(a)anthracene and the noncarcinogenic potential of the other compounds examined. The data indicated that the metabolic activation of nonfunctional carcinogenic aromatic hydrocarbons was due to the introduction of an alkyl group in a highly reactive mesoanthracenic center in the molecule. Further investigation is necessary to determine whether the bioalkylation reaction can be used as a general probe for the carcinogenic activity of nonfunctional polynuclear aromatic hydrocarbons. |
| Additional Infomation |
Perylene is an ortho- and peri-fused polycyclic arene comprising of five benzene rings that is anthracene in which the d,e and k,l sides are fused to benzene rings. It is an ortho- and peri-fused polycyclic arene and a member of perylenes.
A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic. |
| Molecular Formula |
C20H12
|
|---|---|
| Molecular Weight |
252.31
|
| Exact Mass |
252.093
|
| CAS # |
198-55-0
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| Related CAS # |
Perylene-d12;1520-96-3
|
| PubChem CID |
9142
|
| Appearance |
Yellow to colorless crystals from toluene
Golden-brown yellow plates from benzene, acetic acid |
| Density |
1.3±0.1 g/cm3
|
| Boiling Point |
467.5±12.0 °C at 760 mmHg
|
| Melting Point |
277-280ºC
|
| Flash Point |
228.6±13.7 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.887
|
| LogP |
6.4
|
| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
0
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
20
|
| Complexity |
304
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1=CC2=C3C(=C1)C4=CC=CC5=C4C(=CC=C5)C3=CC=C2
|
| InChi Key |
CSHWQDPOILHKBI-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C20H12/c1-5-13-6-2-11-17-18-12-4-8-14-7-3-10-16(20(14)18)15(9-1)19(13)17/h1-12H
|
| Chemical Name |
perylene
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 3.33 mg/mL (13.20 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9634 mL | 19.8169 mL | 39.6338 mL | |
| 5 mM | 0.7927 mL | 3.9634 mL | 7.9268 mL | |
| 10 mM | 0.3963 mL | 1.9817 mL | 3.9634 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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