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| Other Sizes |
| ln Vitro |
Diallyldimethylammonium chloride (60 percent in water) is a biochemical reagent that can be utilized in research pertaining to life sciences as an organic compound or biological material.
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| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Male albino rats were placed in metabolism cages. Following intubation with 14-C diallyldimethylammonium chloride (DADMAC), one animal per time point, urine and feces were collected at 24, 48 and 72 hours. Animals were treated with 656 mg/kg (24 hours); 1585 mg/kg (48 hours) or 1591 mg/kg (72 hours) of 14-C DADMAC (100 microcuries/mL: 100 microcuries/0.9 grams. purity unspecified). Carcasses were frozen and radioactivity determined later in blood, spleen, liver, kidneys, bone marrow, and three sections of gastrointestinal tract. Carcasses, after removal of skin and feet were homogenized and radioactivity determined. While this study has marked deficiencies, it demonstrates that DADMAC is poorly absorbed. No change in clinical signs was observed in the treated animals. There was a slight weight loss in the study. The primary route of excretion for 14-C derived from DADMAC monomer was feces. ...The tissue levels for monomer were very low at each time point and there was no accumulation in any organ. The highest concentration of any organ was liver at 24 hours which had 0.0034% of the administered radioactivity. DADMAC was poorly absorbed. Of the tissues studied, the liver was found to have the largest percent uptake. The principal route of excretion was via the feces followed by the urinary pathway with a very low amount being excreted via the expired air. The largest elimination was observed to occur during the first 24 hours. |
| Toxicity/Toxicokinetics |
Non-Human Toxicity Values
LD50 Rat (Wistar) oral 3930 mg/kg LD50 Rat (Sprague-Dawley) oral 2520 mg/kg |
| Additional Infomation |
See also: Polyquaternium-6 (15000 MW) (annotation moved to).
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| Molecular Formula |
C8H16CLN
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|---|---|
| Molecular Weight |
161.67
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| Exact Mass |
161.097
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| CAS # |
7398-69-8
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| Related CAS # |
26062-79-3;28301-34-0 (Parent)
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| PubChem CID |
33286
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| Appearance |
Solid
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| Density |
(25ºC)=1.04
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| Boiling Point |
100ºC
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| Melting Point |
140-148 °C
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| Index of Refraction |
n20/D 1.460
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
10
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| Complexity |
91.1
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C=CC[N+](C)(C)CC=C.[Cl-]
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| InChi Key |
GQOKIYDTHHZSCJ-UHFFFAOYSA-M
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| InChi Code |
InChI=1S/C8H16N.ClH/c1-5-7-9(3,4)8-6-2;/h5-6H,1-2,7-8H2,3-4H3;1H/q+1;/p-1
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| Chemical Name |
dimethyl-bis(prop-2-enyl)azanium;chloride
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.1854 mL | 30.9272 mL | 61.8544 mL | |
| 5 mM | 1.2371 mL | 6.1854 mL | 12.3709 mL | |
| 10 mM | 0.6185 mL | 3.0927 mL | 6.1854 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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