| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
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| Other Sizes |
|
| Targets |
IC50: 1 nM (CRLR/RAMP1, cell assay), 300 nM (CRLR/RAMP2, cell assay)[1]
|
|---|---|
| ln Vitro |
Human β-CGRP is a calcitonin peptide that functions via a complex of calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein (RAMP) with an IC50 of 1 nM. NG108-15 and HEK293T cells that express CRLR and RAMP2 express 130 nM and 300 nM, respectively [1]. SK-N-MC and Swiss 3T3 cells both express CRLR and RAMP1, and SK-N-MC and Swiss 3T3 cells express both CRLR and RAMP1 [1]. In addition to being a strong vasodilator, CGRP has anti- and pro-inflammatory properties [2].
|
| References |
| Molecular Formula |
C164H268F3N51O50S3
|
|---|---|
| Molecular Weight |
3907.38
|
| Appearance |
Typically exists as solid at room temperature
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O :~100 mg/mL (~25.59 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (12.80 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.2559 mL | 1.2796 mL | 2.5593 mL | |
| 5 mM | 0.0512 mL | 0.2559 mL | 0.5119 mL | |
| 10 mM | 0.0256 mL | 0.1280 mL | 0.2559 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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