| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
2-Amino-6-chloropurine is a starting point for the creation of nucleotide analogs that have antiviral properties against the human herpesvirus 6 (HHV-6) and the Epstein-Barr virus (EBV). 11. (Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine Qiu, Y.-L., Ksebati, MB, Ptak, RG, et al. New nucleotide analogs possessing wide-ranging antiviral efficacy 1998; J. Med. Chemistry 41(1): 10–23
|
|---|---|
| References | |
| Additional Infomation |
6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.
|
| Molecular Formula |
C5H4CLN5
|
|---|---|
| Molecular Weight |
169.57
|
| Exact Mass |
169.015
|
| CAS # |
10310-21-1
|
| PubChem CID |
5360349
|
| Appearance |
Off-white to light yellow solid powder
|
| Density |
1.8±0.1 g/cm3
|
| Boiling Point |
315.2ºC at 760mmHg
|
| Melting Point |
>300 °C(lit.)
|
| Flash Point |
144.4ºC
|
| Vapour Pressure |
1.75E-15mmHg at 25°C
|
| Index of Refraction |
1.827
|
| LogP |
-0.03
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
11
|
| Complexity |
154
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
RYYIULNRIVUMTQ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
|
| Chemical Name |
6-chloro-7H-purin-2-amine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 33.33 mg/mL (196.56 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.74 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.8973 mL | 29.4863 mL | 58.9727 mL | |
| 5 mM | 1.1795 mL | 5.8973 mL | 11.7945 mL | |
| 10 mM | 0.5897 mL | 2.9486 mL | 5.8973 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
