| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| Targets |
FGFR1 9.9 nM (IC50) FGFR2 3.1 nM (IC50) FGFR3 16 nM (IC50) FGFR4 1.8 nM (IC50)
|
|---|---|
| ln Vitro |
FGFR-IN-11 (0.3 nM–20 μM, 72 h) has nanomolar activity to stop the proliferation of different types of cancer cells [1].
|
| ln Vivo |
In female nude mice, FGFR-IN-11 (60 mg/kg, orally, once day for 21 days) dramatically reduced tumor growth in Huh-7 or NCI-H1581 xenograft tumor models without changing the mice's body weight.[1]
|
| Cell Assay |
Cell Viability Assay[1]
Cell Types: NCI-H1581, SNU16, Huh-7, Hep3B Tested Concentrations: 0.3 nM-20 μM Incubation Duration: 72 h Experimental Results: Inhibited cell growth with IC50 values of less than 2 nM (NCI-H1581 and SNU16), 15.63 nM (Huh-7) and 52.6 nM (Hep3B). |
| Animal Protocol |
Animal/Disease Models: Huh-7 xenograft model in female nude mice[1]
Doses: 15, 30, 60 mg/kg Route of Administration: Oral administration (po) Experimental Results: Inhibited tumor growth of 88.2% at the dose of 60 mg/ kg and had no significant changes in body weight. Animal/Disease Models: NCI-H1581 xenograft model in female nude mice[1] Doses: 60 mg/kg Route of Administration: Oral administration (po) Experimental Results: Inhibited tumor growth of 67% and had no significant changes in body weight. |
| References |
| Molecular Formula |
C28H29CLN4O4
|
|---|---|
| CAS # |
2658488-68-5
|
| Appearance |
Typically exists as solid at room temperature
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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