Size | Price | Stock | Qty |
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5mg |
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10mg |
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Other Sizes |
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Targets |
δ Opioid Receptor/DOR
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ln Vitro |
[Met5]-Enkephalin dramatically lowers the total number of glial cells in culture at concentrations of 0.1 nM, 10 nM, and 1 μM [1]. Cats' pelvic nerve-induced distal colon contractions are inhibited by [Met5]-Enkephalin, amide, which works through delta-opioid receptors. [Met5]-enkephalin has an IC50 value of 2.2 nM and inhibits pelvic nerve-evoked contractions in a concentration-dependent and reversible manner. At a high dosage (3 nM), [Met5]enkephalin strongly suppresses neurogenic contractions, but exogenous acetylcholine-induced contractions are unaffected [2].
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References |
[1]. Stiene-Martin A, et al. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48.
[2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. |
Molecular Formula |
C29H37F3N6O8S
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Molecular Weight |
686.70
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CAS # |
2918768-28-0
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Related CAS # |
[Met5]-Enkephalin, amide;60117-17-1
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O: 100 mg/mL (145.62 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (72.81 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.4562 mL | 7.2812 mL | 14.5624 mL | |
5 mM | 0.2912 mL | 1.4562 mL | 2.9125 mL | |
10 mM | 0.1456 mL | 0.7281 mL | 1.4562 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.