| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| Targets |
Tau aggregation[1]
|
|---|---|
| ln Vivo |
Sarkosyl-insoluble Tau is decreased by direct intraventricular injection of BSc3094 (3 mg/kg)[1]. By restoring the paired-pulse depression seen in pro-aggregant Tau slices that were not treated following the application of a paired-pulse stimulus of the Schaffer collaterals, BSc3094 rescues the pre-synaptic deficit in organotypic hippocampus slices from pro-aggregant animals. In rTg4510 mice, BSc3094 restores the increase in Tau phosphorylation levels to the baseline level. In rTg4510 mice, BSc3094 partially improved memory deficits[1].
|
| Animal Protocol |
Animal/Disease Models: Mice[1]
Doses: 3 mg/kg Route of Administration: Iv Experimental Results: Direct intraventricular administration decreased sarkosyl-insoluble Tau. Animal/Disease Models: rTg4510 mice[1] Doses: 0.075~1.5 mM Route of Administration: Intraventricular administration Experimental Results: decreased the levels of sarkosyl-insoluble Tau in cortical extracts by ≈70%. |
| References |
| Molecular Formula |
C17H12N6O3S
|
|---|---|
| Molecular Weight |
380.38
|
| Exact Mass |
380.069
|
| CAS # |
946857-84-7
|
| PubChem CID |
25096749
|
| Appearance |
Yellow to orange solid powder
|
| LogP |
4.338
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
27
|
| Complexity |
553
|
| Defined Atom Stereocenter Count |
0
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 33.33 mg/mL (87.62 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.57 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6289 mL | 13.1447 mL | 26.2895 mL | |
| 5 mM | 0.5258 mL | 2.6289 mL | 5.2579 mL | |
| 10 mM | 0.2629 mL | 1.3145 mL | 2.6289 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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