| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| Targets |
mGluR
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|---|---|
| ln Vitro |
Analogs of excitatory amino acids (EAAs) stimulate receptors, which in turn cause phosphoinositides (PIs) to hydrolyze more readily. In these investigations, hippocampal slices from neonatal rats—rats that are 6–11 days old—are used to examine how EAA analogs affect these receptors. 51 μM of trans-ACPD is the concentration needed to elicit half-maximal stimulation (EC50 value). The IC50 values of DL-2-Amino-3-phosphonopropionate (DL-AP3) range from 480 to 850 μM, making it an effective inhibitor of PI hydrolysis triggered by ibotenate, quisqualate, and trans-ACPD.
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| ln Vivo |
When mice get intrathecal injections of NMDA, kainate, trans-ACPD, TNF-α, or IL-1β, their biting behavior is significantly (p<0.001) more aggressive than when mice receive intrathecal injections of saline. When compared to mice treated with saline (10 mL/kg, ip), systemic pre-treatment with GM (100 mg/kg, ip) significantly (p<0.001) reduced the biting behavior in all groups. With the following suppression percentages for pro-inflammatory cytokines and NMDA, GM has the largest effect: 92±7% for TNF-α, 91±5% for IL-1β, 69±1% for NMDA, and 71±12% for trans-ACPD. On the other hand, GM had no discernible impact on the kainate-mediated biting response at the same dosage[3].
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| References |
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| Molecular Formula |
C7H11NO4
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|---|---|
| Molecular Weight |
173.17
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| Exact Mass |
173.069
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| CAS # |
67684-64-4
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| Related CAS # |
(1S,3R)-ACPD;111900-32-4;cis-ACPD;477331-06-9
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| PubChem CID |
104766
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| Appearance |
White to off-white solid powder
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| LogP |
0.353
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
12
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| Complexity |
227
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| Defined Atom Stereocenter Count |
2
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| SMILES |
C1C[C@](C[C@@H]1C(=O)O)(C(=O)O)N
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| InChi Key |
YFYNOWXBIBKGHB-FBCQKBJTSA-N
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| InChi Code |
InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m1/s1
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| Chemical Name |
(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 50 mg/mL (288.73 mM)
H2O: 3.57 mg/mL (20.62 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.44 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.44 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. View More
Solubility in Formulation 3: 5 mg/mL (28.87 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication (<60°C). |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.7747 mL | 28.8734 mL | 57.7467 mL | |
| 5 mM | 1.1549 mL | 5.7747 mL | 11.5493 mL | |
| 10 mM | 0.5775 mL | 2.8873 mL | 5.7747 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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