| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| Targets |
BACE-1[1]
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|---|---|
| ln Vitro |
In a cell-based experiment, elenebecestat (E2609) has an IC50 of around 7 nmol/L, making it a strong BACE1 inhibitor[2]. It has been demonstrated that elenebecestat lowers the generation of Ab in rodent plasma, brain, and cerebrospinal fluid (CSF)[2].
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| ln Vivo |
Potently inhibiting the synthesis of Ab1-40 and Ab1-42 in the plasma and CSF of non-human primates is elenbecestat (E2609; 0.3-30 mg/kg; po)[2]. Following a single daily dosage, elenebecestat exhibits a plasma half-life of 12–16 hours[1].
|
| Animal Protocol |
Animal/Disease Models: Cynomolgus monkeys (pharmacokinetic/PK analysis)[2]
Doses: 0.3 mg/kg; 1 mg/kg; 3 mg/kg; 30 mg/kg Route of Administration: Oral administration Experimental Results: Potently inhibits Ab1- 40 and Ab1-42 production in the plasma and CSF. |
| References | |
| Additional Infomation |
Elenbecestat is under investigation in clinical trial NCT02956486 (A 24-Month Study to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Subjects With Early Alzheimer's Disease).
|
| Molecular Formula |
C19H18F3N5O2S
|
|---|---|
| Molecular Weight |
437.438732624054
|
| Exact Mass |
437.113
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| CAS # |
1388651-30-6
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| PubChem CID |
57827330
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| Appearance |
Light yellow to yellow solid powder
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| LogP |
1.4
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
9
|
| Rotatable Bond Count |
4
|
| Heavy Atom Count |
30
|
| Complexity |
687
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| Defined Atom Stereocenter Count |
3
|
| SMILES |
S1C(N)=N[C@@]2(C3C(=CC=C(C=3)NC(C3C=NC(C(F)F)=CN=3)=O)F)CO[C@H](C)[C@H]2C1
|
| InChi Key |
AACUJFVOHGRMTR-DPXNYUHVSA-N
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| InChi Code |
InChI=1S/C19H18F3N5O2S/c1-9-12-7-30-18(23)27-19(12,8-29-9)11-4-10(2-3-13(11)20)26-17(28)15-6-24-14(5-25-15)16(21)22/h2-6,9,12,16H,7-8H2,1H3,(H2,23,27)(H,26,28)/t9-,12-,19-/m1/s1
|
| Chemical Name |
N-[3-[(4aS,5R,7aS)-2-amino-5-methyl-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide
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| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ≥ 250 mg/mL (571.51 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.75 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.75 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2860 mL | 11.4301 mL | 22.8603 mL | |
| 5 mM | 0.4572 mL | 2.2860 mL | 4.5721 mL | |
| 10 mM | 0.2286 mL | 1.1430 mL | 2.2860 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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