| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| Targets |
TPC2[1]
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|---|---|
| ln Vitro |
With an IC50 value of 3.7 μM, SG-094 (72 hours) exhibits anti-proliferative effects on RIL175 cells[1]. SG-094 (10 μM) inhibits TPC2 currents produced by PI(3,5)P2 on endolysosomes that are separated from HEK293 cells that express TPC2-EGFP [1]. Without lowering their total protein levels, SG-094 (10 μM; pretreatment for 1 h) dramatically decreased VEGF-induced activation of eNOS, JNK, MAPK, and AKT in HUVEC [1]. After glucose fasting, RIL175 WT cells' OCR/ECAR ratio rises in response to SG-094 (1–5 μM; pretreated for 1 hour) [1].
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| ln Vivo |
In mice, SG-094 (90 nmol/kg; administered every 2-3 days for a 10-day period) suppresses the formation of hepatocellular carcinoma (HCC) tumors[1].
|
| Cell Assay |
Western Blot Analysis[1]
Cell Types: HUVECs Tested Concentrations: 10 μM Incubation Duration:Pretreated for 1 h before stimulation with VEGF-A165 for 15 min Experimental Results: Dramatically diminished VEGF-induced phosphorylation of several downstream targets, such as eNOS, JNK, MAPK , and AKT. |
| Animal Protocol |
Animal/Disease Models: C57Bl/6-Tyr mice were injected with RIL175 WT cells[1]
Doses: 90 nmol/kg Route of Administration: Every 2-3 days over a 10-day timescale Experimental Results: Inhibited tumor growth. |
| References |
| Molecular Formula |
C30H29NO3
|
|---|---|
| Molecular Weight |
451.556168317795
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| Exact Mass |
451.21
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| Elemental Analysis |
C, 79.80; H, 6.47; N, 3.10; O, 10.63
|
| CAS # |
2922283-37-0
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| PubChem CID |
162679540
|
| Appearance |
Light brown to brown solid powder
|
| LogP |
6.8
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| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
34
|
| Complexity |
594
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O(C1C=CC=CC=1)C1C(=CC2CCN(C)C(CC3C=CC(=CC=3)OC3C=CC=CC=3)C=2C=1)OC
|
| InChi Key |
BTNHPUSFPKFAPU-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C30H29NO3/c1-31-18-17-23-20-29(32-2)30(34-25-11-7-4-8-12-25)21-27(23)28(31)19-22-13-15-26(16-14-22)33-24-9-5-3-6-10-24/h3-16,20-21,28H,17-19H2,1-2H3
|
| Chemical Name |
6-methoxy-2-methyl-7-phenoxy-1-[(4-phenoxyphenyl)methyl]-3,4-dihydro-1H-isoquinoline
|
| Synonyms |
SG-094; SG 094; SG094
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
Methanol: 125 mg/mL (276.82 mM)
DMSO: 100 mg/mL (221.45 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.54 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.54 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2145 mL | 11.0727 mL | 22.1455 mL | |
| 5 mM | 0.4429 mL | 2.2145 mL | 4.4291 mL | |
| 10 mM | 0.2215 mL | 1.1073 mL | 2.2145 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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