Size | Price | Stock | Qty |
---|---|---|---|
10mg |
|
||
50mg |
|
||
100mg |
|
||
500mg |
|
||
Other Sizes |
|
ln Vitro |
Dihydroorotate dehydrogenase (DHODH), a crucial mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly growing cells, is the primary enzyme that teriflunomide inhibits. It is possible that teriflunomide, which is a cytostatic rather than a cytotoxic medication to leukocytes, lessens the inflammatory response to autoantigens in MS by inhibiting the activity of high-avidity proliferating T lymphocytes and B lymphocytes[1].
|
---|---|
ln Vivo |
In two different animal models of demyelinating illness, teriflunomide has proven to have positive effects. Teriflunomide administration produces clinical, histological, and electrical evidence of efficacy as a preventative and therapeutic drug in the dark agouti rat model of experimental autoimmune encephalitis (EAE). Similar to this, teriflunomide treatment delays the development of the disease and its severity in the female Lewis rat model of EAE[1]. This has positive preventative and therapeutic clinical benefits.
|
References |
[1]. Oh J, et al. An update of teriflunomide for treatment of multiple sclerosis. Ther Clin Risk Manag. 2013;9:177-90.
|
Molecular Formula |
C12H9F3N2O2
|
---|---|
Molecular Weight |
270.21
|
CAS # |
163451-81-8
|
Related CAS # |
(E/Z)-Teriflunomide;108605-62-5
|
Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
|
SMILES |
FC(C1C([H])=C([H])C(=C([H])C=1[H])N([H])C(/C(/C#N)=C(/C([H])([H])[H])\O[H])=O)(F)F
|
HS Tariff Code |
2934.99.9001
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
DMSO: 33.33 mg/mL (123.35 mM)
|
---|---|
Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.25 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.25 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.7008 mL | 18.5041 mL | 37.0083 mL | |
5 mM | 0.7402 mL | 3.7008 mL | 7.4017 mL | |
10 mM | 0.3701 mL | 1.8504 mL | 3.7008 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.