| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| Targets |
AT1 Receptor
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|---|---|
| ln Vitro |
The growth of cultured vascular smooth muscle cells is inhibited by angiotensin 1-7 (Ang-(1-7)), while cell growth is stimulated by an equal molar concentration of Ang II[2]. ?The methylglyoxal-modified albumin (MGA)-stimulated myofibroblast phenotype is abolished by angiotensin 1-7 (Ang 1-7) through the suppression of the TGF-β-ERK pathway's chronic stimulation in NRK-52E cells[4]. ?In contrast to Ang II/angiotensin II type 1 receptor (AT1R), angiotensin 1-7 signals through the Mas receptor (MasR), promoting anti-inflammatory, vasodilatory, and neuroprotective effects[5].
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| ln Vivo |
Angiotensin 1-7 (Ang-(1-7)) therapy on a daily basis (0.01-0.06 mg/kg) significantly reduces colitis brought on by DSS. Treatment with Ang 1-7 reduces the phosphorylation of p38, ERK1/2, and Akt associated with colitis[3].
|
| References |
|
| Molecular Formula |
C43H66N12O13
|
|---|---|
| Molecular Weight |
959.056749820709
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| Exact Mass |
958.487
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| CAS # |
2855063-75-9
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| Related CAS # |
Talfirastide;51833-78-4
|
| PubChem CID |
132976063
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| Appearance |
White to off-white solid powder
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| Hydrogen Bond Donor Count |
13
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| Hydrogen Bond Acceptor Count |
16
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| Rotatable Bond Count |
25
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| Heavy Atom Count |
68
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| Complexity |
1690
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| Defined Atom Stereocenter Count |
8
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| SMILES |
O=C([C@H](CC1=CN=CN1)NC([C@H]([C@@H](C)CC)NC([C@H](CC1C=CC(=CC=1)O)NC([C@H](C(C)C)NC([C@H](CCC/N=C(\N)/N)NC([C@H](CC(=O)O)N)=O)=O)=O)=O)=O)N1CCC[C@H]1C(=O)O.OC(C)=O
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| InChi Key |
VJHCETPHKAQOHY-LBGFTJIYSA-N
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| InChi Code |
InChI=1S/C41H62N12O11.C2H4O2/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56;1-2(3)4/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46);1H3,(H,3,4)/t22-,26-,27-,28-,29-,30-,32-,33-;/m0./s1
|
| Chemical Name |
acetic acid;(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 62.5 mg/mL (65.17 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (104.27 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.0427 mL | 5.2134 mL | 10.4269 mL | |
| 5 mM | 0.2085 mL | 1.0427 mL | 2.0854 mL | |
| 10 mM | 0.1043 mL | 0.5213 mL | 1.0427 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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