| Size | Price | |
|---|---|---|
| 5g | ||
| Other Sizes |
| Targets |
Human Endogenous Metabolite
(2-Aminoethyl)phosphonic acid targets phosphonate metabolism pathways and is used as a phosphorus source by various microorganisms. It is an endogenous metabolite primarily detected in urine. The compound may interact with enzymes involved in phosphonate transport and metabolism, such as phosphonate transporters and C-P lyase enzymes. |
|---|---|
| ln Vitro |
In vitro, (2-aminoethyl)phosphonic acid is used as a growth medium component for the marine bacterium Roseovarius nubinhibens ISM. It serves as a phosphorus source for bacteria that can utilize phosphonates. The compound is also used in studies of phosphonate metabolism and the enzymatic cleavage of the carbon-phosphorus bond.
|
| ln Vivo |
In vivo, (2-aminoethyl)phosphonic acid is an endogenous metabolite found in urine. It is present in the body as a result of normal metabolism and may be derived from dietary sources or endogenous synthesis. Its role in human physiology is not well-characterized, but it is part of the phosphonate pool in the body.
|
| Enzyme Assay |
In vitro enzyme assays for (2-aminoethyl)phosphonic acid typically measure the activity of enzymes that metabolize phosphonates, such as C-P lyase or phosphonate dehydrogenases. The compound is used as a substrate to study enzyme kinetics and the mechanisms of carbon-phosphorus bond cleavage. Assays are performed using bacterial cell extracts or purified enzymes, and the reaction products are analyzed by chromatographic methods.
|
| Cell Assay |
In vitro cell experiments with (2-aminoethyl)phosphonic acid are not extensively documented. The compound may be used in bacterial culture studies to assess the utilization of phosphonates as a phosphorus source. The growth of bacteria in media containing (2-aminoethyl)phosphonic acid as the sole phosphorus source is monitored to study phosphonate metabolism.
|
| Animal Protocol |
In vivo animal experiments with (2-aminoethyl)phosphonic acid are not well-characterized. As an endogenous metabolite, it is present in biological fluids and tissues. Studies on phosphonate metabolism in animal models may involve administering phosphonates and measuring the levels of (2-aminoethyl)phosphonic acid and other metabolites to assess metabolic pathways and enzyme activities.
|
| ADME/Pharmacokinetics |
Pharmacokinetic data for (2-aminoethyl)phosphonic acid are limited. As a small, polar phosphonate, it is expected to be readily excreted in urine. It may be absorbed from the diet or synthesized endogenously. The compound is stable and has a relatively simple structure, making it suitable for use as a model compound in phosphonate metabolism studies.
|
| Toxicity/Toxicokinetics |
Toxicological data for (2-aminoethyl)phosphonic acid are limited. As an endogenous metabolite, it is generally considered to have low toxicity. However, comprehensive toxicological studies have not been performed. The compound is intended for research use only and not for human consumption.
|
| Additional Infomation |
(2-Aminoethyl)phosphonic acid is a phosphonic acid in which the hydrogen atom on the phosphorus atom is replaced by a 2-aminoethyl group. It is a metabolite found in humans and mice. It belongs to the phosphonic acid class and is also a primary amino compound. Functionally, it is related to phosphonic acids. It is the zwitterion tautomer of (2-aminoethyl)phosphonic acid. (2-Aminoethyl)phosphonic acid has been reported in Homo sapiens, Streptomyces regenerativelis, and other organisms with relevant data. It is an organophosphorus compound isolated from human and animal tissues.
(2-Aminoethyl)phosphonic acid is a research compound with applications in microbiology, metabolomics, and biochemistry. It is used to study phosphonate metabolism and as a phosphorus source for bacterial cultures. No clinical trials or approved therapeutic indications exist for this compound. Its mechanism of action involves the cleavage of the carbon-phosphorus bond by C-P lyase enzymes in phosphonate-utilizing bacteria. |
| Molecular Formula |
C2H8NO3P
|
|---|---|
| Molecular Weight |
125.06
|
| Exact Mass |
125.024
|
| CAS # |
2041-14-7
|
| PubChem CID |
339
|
| Appearance |
White to off-white solid powder
|
| Density |
1.482g/cm3
|
| Boiling Point |
352.5ºC at 760mmHg
|
| Melting Point |
296 °C (dec.)(lit.)
|
| Flash Point |
167ºC
|
| Vapour Pressure |
6.5E-06mmHg at 25°C
|
| LogP |
-4.8
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
2
|
| Heavy Atom Count |
7
|
| Complexity |
86.9
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
C(CP(=O)(O)O)N
|
| InChi Key |
QQVDJLLNRSOCEL-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C2H8NO3P/c3-1-2-7(4,5)6/h1-3H2,(H2,4,5,6)
|
| Chemical Name |
2-aminoethylphosphonic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O: 66.67 mg/mL (533.10 mM)
DMSO: < 1 mg/mL |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (799.62 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.9962 mL | 39.9808 mL | 79.9616 mL | |
| 5 mM | 1.5992 mL | 7.9962 mL | 15.9923 mL | |
| 10 mM | 0.7996 mL | 3.9981 mL | 7.9962 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
