| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| Other Sizes |
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| Targets |
Human Endogenous Metabolite
|
|---|---|
| ln Vitro |
SY-640 reduces the quantity of cells that invade the liver and lessens the elevation in leukocyte function-associated antigen-1 expression on these cells[1].
|
| ln Vivo |
Although a single dosage has little impact, SY-640 (oral; 150 mg/kg; once daily for 7 days) effectively reduces liver injury produced by lipopolysaccharide and Propionibacterium acnes[1]. In mice, SY-640 (po; 150 mg/kg; once daily for three days) dramatically raises the amount of liver microsomal cytochrome P-450 and the activity of aminopyrine demethylase. Two hours after oral SY-640 treatment, there is a clear inhibition of the hepatic microsomal aminopyrine demethylase activity[2].
|
| References |
|
| Molecular Formula |
C11H13NO3
|
|---|---|
| Molecular Weight |
207.23
|
| Exact Mass |
207.089
|
| CAS # |
168705-70-2
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| PubChem CID |
9837165
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| Appearance |
Light yellow to yellow liquid
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
349.2±21.0 °C at 760 mmHg
|
| Flash Point |
165.0±22.1 °C
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| Vapour Pressure |
0.0±0.8 mmHg at 25°C
|
| Index of Refraction |
1.557
|
| LogP |
0.89
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
15
|
| Complexity |
244
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
C(N(CC1=CC=C2OCOC2=C1)C)(=O)C
|
| InChi Key |
JIWDGIYBLGMPRV-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H13NO3/c1-8(13)12(2)6-9-3-4-10-11(5-9)15-7-14-10/h3-5H,6-7H2,1-2H3
|
| Chemical Name |
N-(1,3-benzodioxol-5-ylmethyl)-N-methylacetamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (482.56 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (12.06 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.8256 mL | 24.1278 mL | 48.2556 mL | |
| 5 mM | 0.9651 mL | 4.8256 mL | 9.6511 mL | |
| 10 mM | 0.4826 mL | 2.4128 mL | 4.8256 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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