| Size | Price | |
|---|---|---|
| Other Sizes |
| ln Vitro |
Phycocyanobilin (100 μM; 0-250 min) prolongs the induction period by inhibiting methyl linoleate peroxidation [1]. The oxidation of liposomes is inhibited by phycocyanobilin (1 mM; 0-300 min) [1].
|
|---|---|
| ln Vivo |
In type 2 diabetic mice, phycocyanobilin (15 mg/kg; po; in diet for 2 weeks) exhibits antioxidant properties[3].
|
| Animal Protocol |
Animal/Disease Models: Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes[3]
Doses: 15 mg/kg Route of Administration: In diet for 2 weeks Experimental Results: Dramatically diminished blood glucose levels. Normalized the increases in urinary 8 -OHdG and 8-epi-PGF2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1. |
| References |
|
| Additional Infomation |
(3E)-phycocyanobilin is a (2R)-phycocyanobilin. It is a conjugate acid of a (3E)-phycocyanobilin(2-).
|
| Molecular Formula |
C33H38N4O6
|
|---|---|
| Molecular Weight |
586.68
|
| Exact Mass |
586.279
|
| CAS # |
20298-86-6
|
| PubChem CID |
20055378
|
| Appearance |
Blue to dark blue solid powder
|
| Density |
1.31±0.1 g/cm3
|
| Boiling Point |
892.1±65.0 °C
|
| LogP |
3.128
|
| Hydrogen Bond Donor Count |
5
|
| Hydrogen Bond Acceptor Count |
7
|
| Rotatable Bond Count |
10
|
| Heavy Atom Count |
43
|
| Complexity |
1460
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
CCC1=C(C(=NC1=O)/C=C\2/C(=C(/C(=C/C3=C(C(=C(N3)/C=C\4/C(=C/C)/[C@H](C(=O)N4)C)C)CCC(=O)O)/N2)CCC(=O)O)C)C
|
| InChi Key |
NNMALANKTSRILL-GSZAROSWSA-N
|
| InChi Code |
InChI=1S/C33H38N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7,13-15,19,34-35H,8-12H2,1-6H3,(H,37,42)(H,38,39)(H,40,41)/b20-7+,24-13-,27-14-,28-15-/t19-/m1/s1
|
| Chemical Name |
3-[(2Z,5Z)-2-[[3-(2-carboxyethyl)-5-[(Z)-[(3E,4R)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-2-yl]methylidene]-5-[(4-ethyl-3-methyl-5-oxopyrrol-2-yl)methylidene]-4-methylpyrrol-3-yl]propanoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: < 1 mg/mL
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 1 mg/mL (1.70 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7045 mL | 8.5225 mL | 17.0451 mL | |
| 5 mM | 0.3409 mL | 1.7045 mL | 3.4090 mL | |
| 10 mM | 0.1705 mL | 0.8523 mL | 1.7045 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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