| Size | Price | |
|---|---|---|
| 100mg | ||
| 500mg | ||
| Other Sizes |
| ln Vitro |
In maize chloroplasts, sethoxydim (0-100 μM, 5 minutes) suppresses acetyl-CoA carboxylase activity [1]. Rapeseed leaf growth rate, chlorophyll content, and lipid content are all inhibited by 1 μM of sethoxydim [1].
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|---|---|
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
In rats, following oral administration, 78.5% is eliminated in the urine and 20.1% in the feces within 48 hr. In a rat metabolism study, excretion was extremely rapid and tissue accumulation was negligible. Metabolism / Metabolites In soya beans, the parent molecule is oxidised, structurally rearranged, and conjugated. Transformation to metabolites is very rapid. |
| Toxicity/Toxicokinetics |
Toxicity Data
LC50 (rat) = 6,280 mg/m3/4h Non-Human Toxicity Values LD50 Rat oral 3200-3500 mg/kg LD50 Rat dermal >5000 mg/kg LD50 Rat (male) oral 3125 mg/kg LD50 Rat (female) oral 2676 mg/kg For more Non-Human Toxicity Values (Complete) data for SETHOXYDIM (8 total), please visit the HSDB record page. |
| References |
|
| Additional Infomation |
Sethoxydim is an oily odorless liquid. Non corrosive. Used as an herbicide.
Sethoxydim is an organic hydroxy compound. Sethoxydim is a selective postemergence herbicide used to control annual and perennial grass weeds in broad-leaved vegetable, fruit, field and ornamental crops. It also has indoor uses. Sethoxydim is moderately toxic by ingestion, and not toxic by dermal absorption. It causes skin and eye irritation. Inhalation of dusts or vapors can cause irritation of the throat and nose. |
| Molecular Formula |
C17H29NO3S
|
|---|---|
| Molecular Weight |
327.48
|
| Exact Mass |
327.187
|
| CAS # |
74051-80-2
|
| PubChem CID |
135491830
|
| Appearance |
Oily liquid
|
| Density |
1.043
|
| Boiling Point |
431.9ºC at 760 mmHg
|
| Melting Point |
>90°C
|
| Flash Point |
215ºC
|
| Index of Refraction |
1.534
|
| LogP |
4.501
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
9
|
| Heavy Atom Count |
22
|
| Complexity |
432
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CCCC(=NOCC)C1=C(CC(CC(C)SCC)CC1=O)O
|
| InChi Key |
CSPPKDPQLUUTND-NBVRZTHBSA-N
|
| InChi Code |
InChI=1S/C17H29NO3S/c1-5-8-14(18-21-6-2)17-15(19)10-13(11-16(17)20)9-12(4)22-7-3/h12-13,19H,5-11H2,1-4H3/b18-14+
|
| Chemical Name |
2-[(E)-N-ethoxy-C-propylcarbonimidoyl]-5-(2-ethylsulfanylpropyl)-3-hydroxycyclohex-2-en-1-one
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
|---|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0536 mL | 15.2681 mL | 30.5362 mL | |
| 5 mM | 0.6107 mL | 3.0536 mL | 6.1072 mL | |
| 10 mM | 0.3054 mL | 1.5268 mL | 3.0536 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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