Size | Price | Stock | Qty |
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5mg |
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10mg |
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Other Sizes |
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Targets |
IC50: 10 μg/mL (Pseudomonas aeruginosa ATP synthase)[1]
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ln Vitro |
Compound 22, also known as ATP synthase inhibitor 2, (0-256 μg/mL; 12-15 h) inhibits Pseudomonas aeruginosa's ability to synthesize ATP, although it does not exhibit whole cell antibiotic activity[1].
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Cell Assay |
Cell Viability Assay[1]
Cell Types: MSSA and WTPA Tested Concentrations: 0-256 μg/mL Incubation Duration: 12-15 hrs (hours) Experimental Results: demonstrated no activities against MSSA and WTPA (MICs>128 μg/mL and >256 μg/mL, respectively). |
References |
[1]. John F. Ciprich, et al. Synthesis and Evaluation of Pseudomonas aeruginosa ATP Synthase Inhibitors. ACS Omega.
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Molecular Formula |
C21H22N2O3S
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Molecular Weight |
382.48
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CAS # |
2814540-76-4
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Related CAS # |
ATP synthase inhibitor 2 TFA
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
C(C1=CC2C=CC=CC=2N=C1SC)N[C@H](C(=O)OC)CC1C=CC(=CC=1)O
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: 250 mg/mL (653.63 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (5.44 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (5.44 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.6145 mL | 13.0726 mL | 26.1452 mL | |
5 mM | 0.5229 mL | 2.6145 mL | 5.2290 mL | |
10 mM | 0.2615 mL | 1.3073 mL | 2.6145 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.