| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| ln Vitro |
In a soft agar experiment, APS6-45 (3-30 nM; 3 weeks) significantly inhibits the growth of TT human Medullary Thyroid Carcinoma (MTC) cell colonies[1]. RAS pathway activity signaling in human MTC cell lines TT and MZ-CRC-1 is substantially inhibited by APS6-45 (1 μM; 1 h)[1].
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|---|---|
| ln Vivo |
APS6-45 (10 mg/kg; po daily for 30 d) does not alter body weight but instead prevents the formation of TT tumors in mice[1]. In mice, APS6-45 (0.1-160 mg/kg; one po) had no discernible harmful effects[1]. In mice, APS6-45 (20 mg/kg; one dose) had a lengthy half-life (5.6 h), a Cmax of 9.7 µM, and an AUC0-24 of 123.7 µM·h[1].
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| Animal Protocol |
Animal/Disease Models: Female nude mice (6 weeks) are implanted with TT cells[1]
Doses: 10 mg/kg Route of Administration: Po daily for 30 days Experimental Results: Led to partial or complete responses in 75% and was well tolerated. Animal/Disease Models: Male ICR mice (6 weeks of age)[1] Doses: 20 mg/kg (pharmacokinetic/PK Analysis) Route of Administration: A single po Experimental Results: T1/2=5.6 h, Cmax=9.7 µM, AUC0-24=123.7 µM •h. |
| References |
| Molecular Formula |
C23H16F8N4O3
|
|---|---|
| Molecular Weight |
548.38537311554
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| Exact Mass |
548.109
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| CAS # |
2188236-41-9
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| PubChem CID |
131953288
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| Appearance |
Off-white to light yellow solid powder
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| LogP |
4.9
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| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
12
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
38
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| Complexity |
806
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| Defined Atom Stereocenter Count |
0
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| SMILES |
FC(C(F)(F)F)(C(F)(F)F)C1C=CC(=C(C=1)NC(NC1C=CC(=CC=1)OC1C=CN=C(C(NC)=O)C=1)=O)F
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| InChi Key |
MVUPJRHPAMCBQJ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C23H16F8N4O3/c1-32-19(36)18-11-15(8-9-33-18)38-14-5-3-13(4-6-14)34-20(37)35-17-10-12(2-7-16(17)24)21(25,22(26,27)28)23(29,30)31/h2-11H,1H3,(H,32,36)(H2,34,35,37)
|
| Chemical Name |
4-[4-[[2-fluoro-5-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 250 mg/mL (455.88 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (3.79 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8235 mL | 9.1176 mL | 18.2352 mL | |
| 5 mM | 0.3647 mL | 1.8235 mL | 3.6470 mL | |
| 10 mM | 0.1824 mL | 0.9118 mL | 1.8235 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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