| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| Other Sizes |
|
| Targets |
S1PR1[1]
|
|---|---|
| ln Vitro |
FTY720 (S)-Phosphate functions as an S1PR1 agonist. FTY720 (S)-Phosphate (Tys, 1 μM) does not affect the induction of S1PR1 ubiquitination, but it does sustain the expression of the S1PR1 protein and improve the human pulmonary artery endothelial cells barrier through S1PR1. Additionally, FTY720 (S)-Phosphate (0.01–50 μM) lessens the recruitment of β-arrestin to S1PR1[1].
|
| ln Vivo |
In mice suffering from bleomycin-induced acute lung injury (ALI), FTY720 (S)-Phosphate (0.5 mg/kg, ip) reduces lung tissue leukocyte infiltration and maintains S1PR1 expression in the lungs[1].
|
| References |
|
| Molecular Formula |
C20H36NO4P
|
|---|---|
| Molecular Weight |
385.477907180786
|
| Exact Mass |
385.238
|
| CAS # |
1142015-10-8
|
| Related CAS # |
FTY720 (S)-Phosphate;402616-26-6
|
| PubChem CID |
42612062
|
| Appearance |
White to off-white solid powder
|
| LogP |
1.1
|
| Hydrogen Bond Donor Count |
4
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
14
|
| Heavy Atom Count |
26
|
| Complexity |
407
|
| Defined Atom Stereocenter Count |
1
|
| SMILES |
C(P(O)(O)=O)C[C@](N)(CO)CCC1=CC=C(CCCCCCCC)C=C1
|
| InChi Key |
XDSPSYJWGHPIAZ-FQEVSTJZSA-N
|
| InChi Code |
InChI=1S/C20H36NO4P/c1-2-3-4-5-6-7-8-18-9-11-19(12-10-18)13-14-20(21,17-22)15-16-26(23,24)25/h9-12,22H,2-8,13-17,21H2,1H3,(H2,23,24,25)/t20-/m0/s1
|
| Chemical Name |
[(3S)-3-amino-3-(hydroxymethyl)-5-(4-octylphenyl)pentyl]phosphonic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 25 mg/mL (64.85 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.49 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5942 mL | 12.9708 mL | 25.9417 mL | |
| 5 mM | 0.5188 mL | 2.5942 mL | 5.1883 mL | |
| 10 mM | 0.2594 mL | 1.2971 mL | 2.5942 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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