| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| Other Sizes |
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| Targets |
GPR14[1]
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|---|---|
| ln Vitro |
Human Urotensin II (U-II) exhibits a strong affinity for recombinant human GPR14, and this binding is functionally linked to the mobilization of calcium. In a HEK-293 cell line expressing human GPR14 (EC50 = 0:62±0.17 nM, n=6), human urotensin II causes concentration-dependent increases in intracellular calcium[1].
|
| ln Vivo |
In anesthetized non-human primates, human urotensin II (U-II) significantly raises total peripheral resistance, a reaction linked to severe heart contractile dysfunction[1].
|
| References |
| Molecular Formula |
C66H86F3N13O20S2
|
|---|---|
| Molecular Weight |
1502.59
|
| Related CAS # |
Urotensin II (114-124), human;251293-28-4
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| Appearance |
Solid powder
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O :~100 mg/mL (~66.55 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (66.55 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.6655 mL | 3.3276 mL | 6.6552 mL | |
| 5 mM | 0.1331 mL | 0.6655 mL | 1.3310 mL | |
| 10 mM | 0.0666 mL | 0.3328 mL | 0.6655 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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