| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| ln Vitro |
Cells will upregulate the amount of ATP1B1 to preserve function and structure in the presence of Transdermal Peptide Disulfide due to the particular binding of Transdermal Peptide Disulfide to ATP1B1; thus, the expression of ATP1B1 increases. But with time, some Transdermal Peptide Disulfide molecules would enter cells through endocytosis; as a result, ATP1B1 expression would decline. The way Transdermal Peptide Disulfide and ATP1B1 interact modifies not only the expression of ATP1B1, but also where it is located and ultimately the epidermal layer's structure. Inhibitors or competitors may lessen this interaction, which would decrease the amount of macromolecular medications that are delivered via the skin[1].
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| References |
| Molecular Formula |
C42H65F3N14O18S2
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|---|---|
| Molecular Weight |
1175.17
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| Related CAS # |
Transdermal Peptide Disulfide;888486-23-5
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| Appearance |
White to off-white solid powder
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O :~100 mg/mL (~85.09 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (85.09 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.8509 mL | 4.2547 mL | 8.5094 mL | |
| 5 mM | 0.1702 mL | 0.8509 mL | 1.7019 mL | |
| 10 mM | 0.0851 mL | 0.4255 mL | 0.8509 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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