| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| Other Sizes |
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| ln Vitro |
It has been demonstrated that neuropeptide Y (human) can shield cortical neurons from the toxicity of Aβ25–35. At 24 and 48 hours, the harmful effects of Aβ25-35 are eliminated by 2 μM NPY. When neurons are pretreated with 1 μM and 0.5 μM Neuropeptide Y(human), the same effect is seen on neuronal survival. In cortical neurons exposed to Aβ35-25, pretreatment with Neuropeptide Y(29-64), amide, human (TFA) increases NGF synthesis, lowers NGF mRNA, and restores NGF release[1].
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| References |
[1]. Croce N, et al. Neuropeptide Y protects rat cortical neurons against β-amyloid toxicity and re-establishes synthesis and release of nerve growth factor. ACS Chem Neurosci. 2012 Apr 18;3(4):312-8.
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| Molecular Formula |
C191H286F3N55O59S
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|---|---|
| Related CAS # |
Neuropeptide Y (human);90880-35-6;[D-Arg25]-Neuropeptide Y (human)
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| Appearance |
Typically exists as solid at room temperature
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O :~100 mg/mL (~22.80 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (22.80 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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