Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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Other Sizes |
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ln Vitro |
MDP1 acetate demonstrates enhanced antibacterial efficacy against S. aureus, E. coli, and P. aeruginosa. The geometric means of MICs for MDP1 are 4.06 μg/mL for S. aureus, 1.22 μg/mL for E. coli, and 3.75 μg/mL for P. aeruginosa, in that order[1]. Assays using DNA, calcein release, and flow cytometry demonstrate a time-dependent antibacterial activity against the tested bacteria that are impacted by MDP1(10, 5, 2.5, 1.25, 0.625, and 0.312 μg/mL) acetate. Ultimately, SEM analyses demonstrate how MDP1 acetate affects S. aureus and E. coli bacteria in a dose- and time-dependent manner by causing vesicle or pore development and cell lysis[1].
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References |
[1]. Akbari R, et al. Action mechanism of melittin-derived antimicrobial peptides, MDP1 and MDP2, de novo designed against multidrug resistant bacteria. Amino Acids. 2018;50(9):1231-1243.
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Molecular Formula |
C113H206N34O30
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Molecular Weight |
2521.05
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Related CAS # |
MDP1
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O :~10 mg/mL (~3.97 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (19.83 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.3967 mL | 1.9833 mL | 3.9666 mL | |
5 mM | 0.0793 mL | 0.3967 mL | 0.7933 mL | |
10 mM | 0.0397 mL | 0.1983 mL | 0.3967 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.