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1g | ||
5g | ||
Other Sizes |
ln Vitro |
Complete protection of MT-4 cells against HIV-1-induced cytopathogenicity is provided by dextran sulfate (25 μg/mL) sodium salt[2].
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ln Vivo |
Models of colitis can be created in animals by using dextran sulfate sodium salt .
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References |
[1]. Regmi S, et, al. Enhanced viability and function of mesenchymal stromal cell spheroids is mediated via autophagy induction. Autophagy. 2021 Oct;17(10):2991-3010.
[2]. Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6. [3]. Araki Y, et, al. Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis. Oncol Rep. 2012 Nov;28(5):1597-605. |
Molecular Formula |
C9H11NO2
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Molecular Weight |
20000
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CAS # |
9011-18-1
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Related CAS # |
Dextran sulfate sodium salt (MW5000);9011-18-1;Dextran sulfate sodium salt (MW 4500-5500);9011-18-1;Dextran sulfate sodium salt (MW 16000-24000);9011-18-1;Dextran sulfate sodium salt (MW 35000-45000);9011-18-1
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
O(CC)C(C1C=CC(=CC=1)N)=O
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : 100 mg/mL
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Solubility (In Vivo) |
Solubility in Formulation 1: 33.33 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.0500 mL | 0.2500 mL | 0.5000 mL | |
5 mM | 0.0100 mL | 0.0500 mL | 0.1000 mL | |
10 mM | 0.0050 mL | 0.0250 mL | 0.0500 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.