| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
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| Targets |
PICK1[1].
|
|---|---|
| ln Vitro |
FSC231 (50 μM) blocks the binding between GluR2 and PICK1 in COS7 cells [2].
|
| ln Vivo |
FSC231 (78.40 μg/kg in total, daily, seven intraperitoneal injections, 3 hours before paclitaxel administration) can alleviate paclitaxel induced neuropathic pain in rats[1]. FSC231 (39.2 μg/kg/day, intraperitoneal injection, for 4 weeks) inhibits the development of diabetic cardiomyopathy in rats, in part by inhibiting ROS generation and apoptosis through the PICK1/eNOS/cGMP pathway[3].
|
| Animal Protocol |
Animal/Disease Models: Paclitaxel induced neuralgia of rats[1]
Doses: 78.40 μg/kg in total Route of Administration: i.p., daily, seven times, completed at 3 h before Paclitaxel Experimental Results: Reversed the changes of inflammatory cytokines (IL‐6, TNF‐α and IL‐10). Inhibited the phosphorylation levels of GSK‐3β and ERK1/2. |
| References |
|
| Molecular Formula |
C13H10CL2N2O3
|
|---|---|
| Molecular Weight |
313.14
|
| CAS # |
1215849-96-9
|
| Appearance |
Solid powder ; White to off-white
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~159.67 mM; with ultrasonication)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.98 mM) (saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you cam add 100 μL of 25.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1935 mL | 15.9673 mL | 31.9346 mL | |
| 5 mM | 0.6387 mL | 3.1935 mL | 6.3869 mL | |
| 10 mM | 0.3193 mL | 1.5967 mL | 3.1935 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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