Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight.By directly controlling target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and member of the nuclear receptor superfamily, vitamin D modifies its biological effects. Vitamin D must undergo two hydroxylation steps in order to become the biologically active hormone 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], which communicates through the VDR, whether it is produced in the skin or consumed. In reaction to vitamin D, the hormone-bound VDR modifies target gene transcription. VDR controls autophagy's transcription at the master level. In breast cancer (BC) cells, vitamin D-activated VDR causes autophagy and an autophagic transcriptional signature.
Vitamin D comes in two different forms. Vitamin D3 (cholecalciferol) is produced in the skin and is found in oily fish and cod liver oil. Vitamin D2 (ergocalciferol) is produced by irradiating yeast and the plant sterol ergosterol. Vitamin D stands for vitamins D2 and D3.
For the treatment of psoriasis, topical medications containing active vitamin D3 (calcitriol, 1,25-dihydroxyvitaminD3, VD3) analogues, such as Tacalcitol, Calcipotriol, and Maxacalcitol, are frequently utilized.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V105414 | VDR agonist 3 | VDR agonist 3 (Compound E15) is a potent vitamin D receptor (VDR) agonist. | |
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V67837 | Vitamin D2-d6 (Ergocalciferol-d6; Calciferol-d6; Ercalciol-d6) | 1311259-89-8 | Vitamin D2-d6 is the deuterium labelled form of Vitamin D2. |
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V67838 | Vitamin D3-d7 (vitamin D3 d7) | 1627523-19-6 | Vitamin D3-d7 is the deuterium labelled form of Vitamin D3. |
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V78432 | Vitamin D4-d5 (22-Dihydroergocalciferol-d5) | Vitamin D4-d5 is the deuterium labelled form of Vitamin D4. | |
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V5290 | Tacalcitol [1,24(R)-Dihydroxyvitamin D3] | 57333-96-7 | Tacalcitol [1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3] is a vitamin D3 analog (isomer of Vitamin D3) that promotes normal bone development by regulating calcium. |
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V17430 | Calcipotriol Monohydrate | 147657-22-5 | Calcipotriolhydrate (Daivonex; Dovonex; MC-903; PRI-2201; Psorcutan; Sorilux), the hydrated form of calcipotriol, is a synthetic calcitriol/Vitamin D3 (VD3)analog and a potent agonist of the VD3 receptor (VDR) used in the treatment of psoriasis and marketed under the trade name Dovonex. |
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V15199 | Dihydrotachysterol | 67-96-9 | Dihydrotachysterol is a novel, synthetic vitamin D analogue that is activated in the liver and does not require renal hydroxylation like vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). |
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V5288 | Paricalcitol (Zemplar) | 131918-61-1 | Paricalcitol (trade name Zemplar) is a novel and potent vitamin D receptor (VDR) agonist developed by Abbott Laboratories for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. |
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V2401 | Doxercalciferol (1α-Hydroxyvitamin D2) | 54573-75-0 | Doxercalciferol (1α-hydroxyvitamin D2; 1alpha-hydroxy VD2), a synthetic vitamin D2 analog, is a potent agonist/activator of VDR (Vitamin D receptor) with important biological activities. |
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V5284 | Vitamin D4 | 511-28-4 | Vitamin D4 (22-Dihydroergocalciferol) is a form of vitamin D developed from fungi. |
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V5286 | Vitamin D2 (Ergocalciferol) | 50-14-6 | Vitamin D2 (Ergocalciferol; Calciferol; Ercalciol) is one form of vitamin D with a double bond on the side chain, which differentiates it from Vitamin D3 (without a double bond on the side chain). |
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V5283 | Cholecalciferol (Vitamin D3) | 67-97-0 | Cholecalciferol (Vitamin D3; Colecalciferol),a secosteroid (a steroid molecule with one ring open), is a naturally occuring form of vitamin D; Upon metabolic activation, cholecalciferol is converted to the active form, 1,25-dihydroxy vitamin D3, which induces cell differentiation and prevents proliferation of cancer cells. |
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V40990 | Calciol (5,6-trans-Vitamin D3) | 22350-41-0 | Calciol (5,6-trans-Vitamin D3), theinactive form of vitamin D3,is an enantiomer of vitamin D3 with important biological roles in calcium homestasis. |
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V12291 | Eldecalcitol | 104121-92-8 | Eldecalcitol is a drug used in Japan for the treatment of osteoporosis. |
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V20462 | Elocalcitol | 199798-84-0 | Elocalcitol (BXL-628; BXL628; BXL 628) is a novel calcitriol andvitamin D3 analogue that can activate vitamin D receptor (VDR). |
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V2037 | Alfacalcidol (1-hydroxycholecalciferol) | 41294-56-8 | Alfacalcidol (1-hydroxycholecalciferol), an active metabolite of Vitamin D, is a potent and non-selective VDR activator medication that has been widely used in the treatment of osteoporosis. |
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V24327 | Maxacalcitol (22-Oxacalcitriol) | 103909-75-7 | Maxacalcitol (22-Oxacalcitriol)is a novel calcitriol analog without hypercalcemic side effects. |
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V41330 | Maxacalcitol-D6 | Maxacalcitol-D6 is the hexa-deuterated form (at the 26,27-dimethyl group) of Maxacalcitol which is a novel calcitriol analog without hypercalcemic side effects. | |
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V1857 | Calcitriol (1,25-Dihydroxyvitamin D3) | 32222-06-3 | Calcitriol (RO215535, Topitriol; 1,25(OH)2D3)is the metabolically/hormonally active form of vitamin D and avitamin D receptor(VDR) agonist. |
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V2435 | Calcifediol (25-hydroxy Vitamin D3) | 19356-17-3 | Calcifediol (also known as 25-hydroxyvitamin D3; 25-hydroxy VD3)is the major circulating metabolite of vitamin D3 in the blood and is the form that is tested inmedicine to determine vitamin D deficiency, namely, the test of 25-hydroxy vitamin D (calcifediol) levels to evaluate how much vitamin D is in the body. |
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