Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight.By directly controlling target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and member of the nuclear receptor superfamily, vitamin D modifies its biological effects. Vitamin D must undergo two hydroxylation steps in order to become the biologically active hormone 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], which communicates through the VDR, whether it is produced in the skin or consumed. In reaction to vitamin D, the hormone-bound VDR modifies target gene transcription. VDR controls autophagy's transcription at the master level. In breast cancer (BC) cells, vitamin D-activated VDR causes autophagy and an autophagic transcriptional signature.
Vitamin D comes in two different forms. Vitamin D3 (cholecalciferol) is produced in the skin and is found in oily fish and cod liver oil. Vitamin D2 (ergocalciferol) is produced by irradiating yeast and the plant sterol ergosterol. Vitamin D stands for vitamins D2 and D3.
For the treatment of psoriasis, topical medications containing active vitamin D3 (calcitriol, 1,25-dihydroxyvitaminD3, VD3) analogues, such as Tacalcitol, Calcipotriol, and Maxacalcitol, are frequently utilized.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V67836 | (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) | 61476-45-7 | (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). |
|
V20676 | Ercalcitriol (RO-17-6218) | 60133-18-8 | Ercalcitriol (RO-17-6218 or 1,25-dihydroxyvitamin D2, 1α,25-Dihydroxy Vitamin D2) is the active metabolite and circulating form of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney. |
|
V67832 | 22-Hydroxyvitamin D3 | 110927-46-3 | 22-Hydroxyvitamin D3 is a novel vitamin D analogue that does not display vitamin D agonist activity in the intestine or bone. |
|
V67843 | 2MD | 213250-70-5 | 2MD is an orally bioactive vitamin D analogue. |
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V5281 | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 | 163018-26-6 | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 analogue. |
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V78546 | Alfacalcidol-d7 (1-hydroxycholecalciferol-d7; 1.alpha.-Hydroxyvitamin D3-d7) | Alfacalcidol-d7 is the deuterated form of Alfacalcidol. | |
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V89109 | Butyrate-Vitamin D3 | 31316-20-8 | Butyrate-Vitamin D3 (Butyrate-Cholecalciferol) is a derivative of vitamin D3 in which one of the hydroxyl groups in the vitamin D3 molecule is replaced by a butyrate group. |
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V67835 | Calcifediol-d3 (25-hydroxy Vitamin D3-d3) | 140710-94-7 | Calcifediol-d3 is the deuterated form of Calcifediol. |
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V67842 | Calcifediol-d6 monohydrate (25-hydroxy Vitamin D3-d6 (monohydrate)) | 2483831-70-3 | Calcifediol-d6 (monohydrate) is the deuterated form of Calcifediol monohydrate. |
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V67840 | Calcitriol-d3 (1,25-Dihydroxyvitamin D3-d3) | 128723-16-0 | Calcitriol-d3 is the deuterated form of Calcitriol. |
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V77044 | Eldecalcitol-d6 (Eldecalcitol d6) | Eldecalcitol-d6 is a deuterated form of Eldecalcitol. | |
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V67833 | MeTC7 | 1817841-22-7 | MeTC7 is a vitamin D receptor (VDR) antagonist. |
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V89108 | Pre-vitamin D3 decanoate | 927822-18-2 | Pre-vitamin D3 decanoate is a derivative of vitamin D3 that can be converted into an active form of vitamin D in the body. |
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V67839 | Previtamin D3 | 1173-13-3 | Previtamin D3 is an intermediate in the preparation /synthesis of cholecalciferol (vitamin D3). |
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V67841 | Pyrocholecalciferol | 10346-43-7 | Pyrocholecalciferol A vitamin D analog generated by the photochemical conversion of 7-dehydrocholesterol (7-DHC). |
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V63206 | Secalciferol-d6 ((24R)-24,25-Dihydroxyvitamin D3-d6) | 1440957-55-0 | Secalciferol-d6 is the deuterated form of Secalciferol. |
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V12071 | TEI-9647 | 173388-20-0 | TEI-9647 (TEI9647) is a vitamin D receptor (VDR) antagonist with immunomodulatory effects. |
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V67834 | TEI-9648 | 173388-21-1 | TEI-9648 is a Vitamin D3 Lactone analogue that is a potent and specific vitamin D receptor (VDR) antagonist. |
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V81726 | VDR agonist 2 | VDR agonist 2 (compound 16i) is a VDR (vitamin D receptor) agonist that can effectively inhibit TGF-β1-induced activation of hepatic stellate cells (HSC). | |
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V67837 | Vitamin D2-d6 (Ergocalciferol-d6; Calciferol-d6; Ercalciol-d6) | 1311259-89-8 | Vitamin D2-d6 is the deuterium labelled form of Vitamin D2. |
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