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NF-κB

NF-κB

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.

NF-κB related products

Structure Cat No. Product Name CAS No. Product Description
ALPK1-IN-3 V82255 ALPK1-IN-3 2765633-73-4 ALPK1-IN-3 (T007) is an inhibitor (blocker/antagonist) of ALPK1.
Andrographolide V0768 Andrographolide 5508-58-7 Andrographolide,a naturally occuring labdane diterpenoid extracted from the stem and leaves of Andrographis paniculata,is anirreversible/covalent NF-κB inhibitor with potential anti-inflammatory activity.
Anti-inflammatory agent 48 V78013 Anti-inflammatory agent 48 anti~inflammatory agent 48 is an anti~inflammatory agent that can inhibit the NF-κB signaling pathway and activates HO-1 expression.
Anti-inflammatory agent 50 V78014 Anti-inflammatory agent 50 Anti-inflammatory agent 50 (compound a1) is an analogue of Fusidic acid and has anti-inflammatory effects.
Anti-inflammatory agent 6 V79544 Anti-inflammatory agent 6 Anti-inflammatory agent 6 blocks the phosphorylation of Iκb kinase α/β (IKKα/β), IκBα and nuclear factor kB p65 (NF-κb p65), which are key controllers of inflammation, thereby showing anti-inflammatory potential.
Anti-inflammatory agent 66 V79083 Anti-inflammatory agent 66 Anti-inflammatory agent 66 (compound 8) is a pterostilbene analogue with anti-inflammatory activity.
Anti-inflammatory agent 7 V78020 Anti-inflammatory agent 7 anti~inflammatory agent 7 inhibits pro-inflammatory cytokines by blocking the NF-κB/MAPK signaling pathway in LPS-treated RAW 264.7 cells and mice.
Anti-inflammatory agent 72 V84376 Anti-inflammatory agent 72
Anti-osteoporosis agent-4 V78049 Anti-osteoporosis agent-4 Anti-osteoporosis agent-4 (Compound 11h) inhibits the differentiation of primary osteoclasts.
Anticancer agent 175 V85829 Anticancer agent 175
Antitumor agent-132 V84948 Antitumor agent-132
Aristolochic acid A V9472 Aristolochic acid A 313-67-7 Aristolochic acid A (Aristolochic acid I; TR 1736) is the major component of the plant extract Aristolochic acids, which is present in the herbs Aristolochia and Asarum.
Asperlactone V82267 Asperlactone 76375-62-7 Asperlactone exhibits anti-inflammatory effect.
Avicularin V30086 Avicularin 572-30-5 Avicularin is a novel and potent flavonoid.
Banksialactone A V82266 Banksialactone A 1135775-06-2 Banksialactone A is a metabolite of the Australian fungus Aspergillus bankianus.
Barlerin V30080 Barlerin 57420-46-9 Barlerin (8-O-Acetyl shanzhiside methyl ester) is a cyclosporine glucoside extracted from a folk medicinal plant in Tibet, China.
Bay 65-1942 HCl V4192 Bay 65-1942 HCl 600734-06-3 Bay 65-1942 HCl is the hydrochloride salt of of BAY65-1942 which is a novel, potent and selective ATP-competitive inhibitor ofIKKβ.
Beauveriolide I V82269 Beauveriolide I 154491-55-1 Beauveriolide I is a metabolite of the entomopathogenic fungus Beauveria sp.
Berbamine V30474 Berbamine 478-61-5 Berbamine is a naturally occuring isoquinoline alkaloidfound in traditional Chinese medicineBarberry with anti-tumor, immunomodulatory and cardiovascular effects.
Berbamine dihydrochloride V29939 Berbamine dihydrochloride 6078-17-7 Berbamine 2HCl is a naturally occuring isoquinoline alkaloid found in traditional Chinese medicine Barberry with anti-tumor, immunomodulatory and cardiovascular effects.
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