Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V76923 | HOIPIN-1 (JTP-0819958) | HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor (antagonist) with IC50 >2.8 μM. | |
|
V86003 | HR488B | ||
|
V84647 | Hyperelamine A | ||
|
V80361 | IMD-ferulic | IMD-ferulic is a covalently linked NF-κB modulator that improves the adjuvant properties of small molecule immune enhancers. | |
|
V1995 | Indole-3-carbinol (I3C) | 700-06-1 | Indole-3-carbinol (I3C; 3-Indolemethanol) is natural product produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. |
|
V73250 | Inotilone (nicotilone) | 906366-79-8 | Inotilone is an inhibitor (blocker/antagonist) of matrix metalloproteinases MMP-2 and MMP-9 and can combat the metastasis of lung cancer cells. |
|
V25186 | INVIVO6620 | 304456-62-0 | BTYNB is a potent and specific inhibitor of IMP1 binding to c-Myc mRNA, with IC50 of 5 μM. |
|
V85966 | Isofalcarintriol | ||
|
V22701 | Isoginkgetin | 548-19-6 | Isoginkgetin is a pre-mRNA splicing inhibitor. |
|
V17869 | Isovitexin | 38953-85-4 | Isovitexin is a flavonoid obtained from passionflower, cannabis and palm. |
|
V2437 | IT-603 | 292168-90-2 | (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). |
|
V80424 | IVMT-Rx-3 | IVMT-Rx-3 is an SDCBP inhibitor targeting the PDZ1 and PDZ2 domains of MDA-9/Syntenin. | |
|
V0765 | JSH-23 | 749886-87-1 | JSH-23 (JSH23; JSH 23) was designed asa nove and potent inhibitor of NF-κB transcriptional activity with potential anti-inflammatory and anti-diabeticactivity. |
|
V4321 | JSH-23 HCL | 749886-87-1 | JSH-23 HCl is designed asan inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line. |
|
V30603 | Kaempferol-3-O-glucorhamnoside | 40437-72-7 | Kaempferol-3-O-glucorhamnoside(astragalin)is a naturally occuring and bioactive flavonoid found in plant Thesium chinense Turcz, that inhibits inflammatory responses via MAPK and NF-κB pathways in vitro and in vivo. |
|
V80483 | Keap1-Nrf2-IN-1 TFA | Keap1-Nrf2-IN-1 TFA (compound35) is a Keap1-Nrf2 protein-protein interaction inhibitor (antagonist) with IC50 of 43 nM for Keap1 protein. | |
|
V85117 | Keap1-Nrf2-IN-17 | ||
|
V82287 | L-Aspartic acid-13C4 (L-Aspartic acid 13C4) | 55443-54-4 | L-Aspartic acid-13C4 is 13C (carbon 13) labelled L-Aspartic acid. |
|
V82279 | L-Aspartic acid-13C4,15N (L-Aspartic acid 13C4,15N) | 202468-27-7 | L-Aspartic acid-13C4,15N is a 13C (carbon 13) and 15N (nitrogen 15) labelled L-Aspartic acid. |
|
V82288 | L-Aspartic acid-15N (L-Aspartic acid 15N) | 3715-16-0 | L-Aspartic acid-15N is a 15N (Nitrogen 15)-labelled L-Aspartic acid. |
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