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NF-κB

NF-κB

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.

NF-κB related products

Structure Cat No. Product Name CAS No. Product Description
L-Serine-d2 ((-)-Serine-d2; (S)-Serine-d2) V82294 L-Serine-d2 ((-)-Serine-d2; (S)-Serine-d2) 95034-57-4 L-Serine-d2 is the deuterium labelled form of L-Serine.
Lacto-N-biose I (Galβ1-3GlcNAc) V82277 Lacto-N-biose I (Galβ1-3GlcNAc) 50787-09-2 Lacto-N-biose I (Galβ1-3GlcNAc) α1,2-focusyltransferase enzyme receptor from Helicobacter pylori, an endogenously produced metabolite.
Laquinimod (ABR-215062) V2219 Laquinimod (ABR-215062) 248281-84-7 Laquinimod(also known as ABR-215062, LAQ) is a potent and orally bioactive immunoregulator being investigated for treatment of multiple sclerosis (MS).
Lasiocarpine V82296 Lasiocarpine 303-34-4 Lasiocarpine is a hepatotoxic pyrrolizidine alkaloid (hepatotoxic PA) that can cause fatal hepatic veno-occlusive disease in the body.
Licoagrochalcone C V82224 Licoagrochalcone C 325144-68-1 Licoagrochalcone C is a flavonoid with inhibitory activity on NF-κB transcription.
Lucioside B V82256 Lucioside B 91174-19-5 Lucyoside B inhibits the production of inflammatory mediators through the NF-κB and activator protein-1 pathways in activated macrophages.
Magnoloside F V84445 Magnoloside F 1945997-27-2
MAT2A-IN-14 V84482 MAT2A-IN-14
MRT 68601 hydrochloride V84634 MRT 68601 hydrochloride 1962928-25-1
Multi-target Pt V85270 Multi-target Pt
N1,N8-Diacetylspermidine V82293 N1,N8-Diacetylspermidine 82414-35-5 N1,N8-Diacetylspermidine is a polyamine found in human urine.
NDMC101 V26329 NDMC101 1308631-40-4 NDMC101 is a potent osteoclastogenesis inhibitor that can suppress osteoclast differentiation by downregulating NFATc1 regulatory gene expression.
Neferine V31378 Neferine 2292-16-2 Neferine is a bisbenzylisoquinoline alkaloid.
Neochlorogenic acid V28831 Neochlorogenic acid 906-33-2 Neochlorogenic acid is a natural polyphenolic compound with anti-inflammatory activity.
Neocryptotanshinone V75096 Neocryptotanshinone (新cryptotanshinone) 109664-02-0 Neocryptotanshinone is a salvia diterpene extracted from Salvia Miltiorrhiza, which inhibits lipopolysaccharide (LPS)-induced inflammation by inhibiting NF-κB and iNOS signaling.
NF-κB-IN-10 V78749 NF-κB-IN-10 NF-κB-IN-10 (compound E1) is an NF-κB inhibitor that can reduce oxidative stress and inflammation by regulating the Nrf2/NF-κB signaling pathway, thereby improving heart failure.
NF-κB-IN-12 V80940 NF-κB-IN-12 NF-κB-IN-12 (compound 3h) is a potent NF-κB inhibitor (antagonist) with IC50 of 1.02 μM.
NF-κB-IN-14 V85763 NF-κB-IN-14 3019972-01-8
NF-κB-IN-9 V77644 NF-κB-IN-9 NF-κB-IN-9 is a sonosensitizer targeting nuclear factor NF-κB (λex/λem=489/628 nm).
NIK SMI1 V26503 NIK SMI1 1660114-31-7 NIK SMI1 (NIK-SMI1) is a novel, highly selective and potent inhibitor of NF-κB-inducing kinase (NIK).
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