Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V6034 | Nimbolide | 25990-37-8 | Nimbolide is a naturally occuringtriterpene/limonoid isolated from the leaves and flowers of neem (Azadirachta indica L), acting as aninhibitor of pancreatic cancer growth and metastasis through ROS-mediated apoptosis. |
|
V82281 | Nrf2 activator-6 | 2728780-74-1 | Nrf2 activator-6 is a tetrahydroisoquinoline compound that is an Nrf2 activator. |
|
V80971 | Nrf2 activator-8 | Nrf2 activator-8 (compound 10e) is an Nrf2 activator (EC50=37.9 nM). | |
|
V78790 | Nrf2 activator-9 | Nrf2 activator-9 (compound D-36) is an Nrf2 activator that can inhibit oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. | |
|
V82290 | Nur77 antagonist 1 | 2378780-25-5 | Nur77 antagonist 1(Compound ja) is a selective Nur77 antagonist. |
|
V34237 | Obtusifolin | 477-85-0 | Isolated from the Cassia obtusifolia seeds, Obtusifolin is natural product of the anthraquinone class. |
|
V28683 | Ophiopogonin D | 945619-74-9 | Ophiopogonin D is a novel and potent C29 steroidal glycoside. |
|
V5343 | Parthenolide | 20554-84-1 | Parthenolide, formerly known as NSC-157035, is a novel sesquiterpene lactone isolated from the medicinal herb Feverfew, acting as a NF-κB activation inhibitor potentially for the treatment of cancer. |
|
V83573 | Penicisteck acid F | ||
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V82262 | Penicitide A | 1338332-27-6 | Penicitide A is a marine secondary metabolite (SM, chemical compound). |
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V84054 | Pheophytin a | 603-17-8 | |
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V81188 | Praelolide | Praelolide is a potent Nrf2 activator. | |
|
V82278 | Pregnanediol 3-glucuronide | 1852-49-9 | Pregnanediol 3-glucuronide is the major terminal metabolite of progesterone and plays an important role in physiological processes such as the female menstrual cycle, pregnancy (supporting pregnancy), embryogenesis, and maternal immune responses in humans and other species. |
|
V84112 | Procyanidin B5 | 12798-57-1 | |
|
V81250 | PTD-p65-P1 Peptide | PTD-p65-P1 Peptide is a potent and specific inhibitor of the nuclear transcription factor NF-κB, derived from the p65 subunit of NF-κB amino acid (AA) residues 271-282. | |
|
V76581 | PTD-p65-P1 Peptide TFA | PTD-p65-P1 Peptide TFA is a potent and specific inhibitor of the nuclear transcription factor NF-κB, derived from the p65 subunit of NF-κB amino acid (AA) residues 271-282, which can selectively inhibit NF induced by various inflammatory stimuli. | |
|
V85876 | Pyridoxine-d3 (Pyridoxol-d3) | 1190043-14-1 | |
|
V3143 | Pyrrolidinedithiocarbamate ammonium | 5108-96-3 | Ammonium pyrrolidine dithiocarbamate (also abbreviated as PDTC) is a potentnuclear factor-κB (NF-κB)inhibitor. |
|
V60047 | Regaloside A | 114420-66-5 | Regaloside A is a novel a phenylpropanoid with anti-inflammatory properties and a significant amount of DPPH radical scavenging activity (58.0% at 160 ppm). |
|
V84186 | Resolvin D5 | 578008-43-2 |
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