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NF-κB

NF-κB

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.

NF-κB related products

Structure Cat No. Product Name CAS No. Product Description
Triptolide-d3 (PG490-d3) V79860 Triptolide-d3 (PG490-d3) Triptolide-d3 is the deuterated form of Triptolide.
Uracil-15N2 (uracil-15N2) V82297 Uracil-15N2 (uracil-15N2) 5522-55-4 Uracil-15N2 is 15N (nitrogen 15) labelled Uracil.
Uracil-d4 (uracil-d4) V82299 Uracil-d4 (uracil-d4) 24897-55-0 Uracil-d4 is the deuterium labelled form of Uracil.
Varioxepine A V82268 Varioxepine A 1623451-72-8 Varioxepine A is a 3H-oxepine-containing alkaloid found in the seaweed-derived endophytic fungus Paecilomyces variotii.
Vitisin A ((+)-Vitisin A) V69821 Vitisin A ((+)-Vitisin A) 142449-89-6 Vitisin A has antioxidant, anticancer, antiapoptotic, neuro-protection, and anti-inflammatory effects.
Withaferin A V11702 Withaferin A 5119-48-2 Withaferin A, a steroidal lactone class of NFkB/IkB Inhibitor, is a natural product extracted from Acnistus arborescens,Withania somnifera (Indian Winter cherry or Ashwagandha in Sanskrit) and other members of Solanaceae family.
Z-VRPR-FMK TFA (VRPR) V81780 Z-VRPR-FMK TFA (VRPR) Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and selective and irreversible inhibitor of mucosa-associated lymphoid tissue lymphoma translocator 1 (MALT1).
Zingerone V13889 Zingerone 122-48-5 Zingerone (Vanillylacetone) is a non-toxic methoxyphenol obtained from ginger and has anti~inflammatory, anti-diabetic, anti-lipid allergy, anti-diarrheal, anti-spasmodic and anti-tumor activities.
α-Lipoic Acid (Thioctic acid) V33981 α-Lipoic Acid (Thioctic acid) 1077-28-7 α-Lipoic Acid (Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid) is a novel organosulfur compound which acts as an antioxidant, and is an essential cofactor of mitochondrial enzyme complexes.
β-D-Fructose (D-fructose (source factory)) V82298 β-D-Fructose (D-fructose (source factory)) 53188-23-1 Beta-D-Fructose is a beta-fructose produced by the hydrolysis of sucrose.
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