Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V79860 | Triptolide-d3 (PG490-d3) | Triptolide-d3 is the deuterated form of Triptolide. | ||
V82297 | Uracil-15N2 (uracil-15N2) | 5522-55-4 | Uracil-15N2 is 15N (nitrogen 15) labelled Uracil. | |
V82299 | Uracil-d4 (uracil-d4) | 24897-55-0 | Uracil-d4 is the deuterium labelled form of Uracil. | |
V82268 | Varioxepine A | 1623451-72-8 | Varioxepine A is a 3H-oxepine-containing alkaloid found in the seaweed-derived endophytic fungus Paecilomyces variotii. | |
V69821 | Vitisin A ((+)-Vitisin A) | 142449-89-6 | Vitisin A has antioxidant, anticancer, antiapoptotic, neuro-protection, and anti-inflammatory effects. | |
V11702 | Withaferin A | 5119-48-2 | Withaferin A, a steroidal lactone class of NFkB/IkB Inhibitor, is a natural product extracted from Acnistus arborescens,Withania somnifera (Indian Winter cherry or Ashwagandha in Sanskrit) and other members of Solanaceae family. | |
V81780 | Z-VRPR-FMK TFA (VRPR) | Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and selective and irreversible inhibitor of mucosa-associated lymphoid tissue lymphoma translocator 1 (MALT1). | ||
V13889 | Zingerone | 122-48-5 | Zingerone (Vanillylacetone) is a non-toxic methoxyphenol obtained from ginger and has anti~inflammatory, anti-diabetic, anti-lipid allergy, anti-diarrheal, anti-spasmodic and anti-tumor activities. | |
V33981 | α-Lipoic Acid (Thioctic acid) | 1077-28-7 | α-Lipoic Acid (Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid) is a novel organosulfur compound which acts as an antioxidant, and is an essential cofactor of mitochondrial enzyme complexes. | |
V82298 | β-D-Fructose (D-fructose (source factory)) | 53188-23-1 | Beta-D-Fructose is a beta-fructose produced by the hydrolysis of sucrose. |