FGFR (Fibroblast growth factor receptors) are the receptors that bind to members of the fibroblast growth factor family of proteins.Pathological conditions involve some of these receptors. Achondroplasia can be brought on by a point mutation in FGFR3. Vertebrates have been found to contain five distinct membrane FGFRs, all of which are members of the tyrosine kinase superfamily (FGFR1, FGFR2, FGFR3, FGFR4, FGFR6). One of the most significant families of paracrine factors that function in the development process is the fibroblast growth factor family. They control which cells differentiate into mesoderm, the production of blood vessels, the growth of limbs, and the growth and differentiation of many different cell types.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V26847 | ODM-203 | 1430723-35-5 | ODM-203 is a potent and orally bioavailable inhibitor of FGFRandVEGFRfamilies inhibitor withIC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. |
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V2723 | PD166866 | 192705-79-6 | PD166866, a member of a new structural class of tyrosine kinase inhibitors, the 6-aryl-pyrido[2,3-d]pyrimidines, is a a new nanomolar potent and selective small molecule inhibitor of FGFR (fibroblast growth factor-1 receptor) tyrosine kinase inhibitor with an IC50 of 52.4 nM. |
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V34674 | Pemigatinib (INCB054828) | 1513857-77-6 | Pemigatinib (formerly INCB054828; INCB-054828; Pemazyre) is a novel, potent, orally bioavailable and selective FGFR inhibitor with IC50 of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. |
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V2780 | PRN1371 | 1802929-43-6 | PRN1371 is a highly selective, potent, covalent, and irreversible FGFR1,2,3,4 inhibitor with IC50 values of 0.6, 1.3, 4.1 and 19.3 nM, respectively. |
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V69482 | Recifercept (TA-46; sFGFR3) | 2226238-09-9 | Recifercept (TA-46) is a soluble recombinant fibroblast growth factor receptor 3 (FGFR3) molecule. |
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V69463 | Resigratinib (KIN-3248) | 2750709-91-0 | Resigratinib (KIN-3248) is an FGFR tyrosine kinase inhibitor (TKI) (antagonist) with anti-tumor effects. |
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V3288 | Roblitinib (FGF 401) | 1708971-55-4 | Roblitinib (FGF-401) is a potent and highly selective inhibitor of human fibroblast growth factor receptor 4 (FGFR4) with an IC50 of 1.9 nM and with potential antineoplastic/anticancer activity. |
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V4215 | Rogaratinib | 1443530-05-9 | Rogaratinib (formerly also known as BAY1163877;BAY-1163877) is a novel, orally available, potent and selectiveinhibitor of aberrant fibroblast growth factor receptor (FGFR) with anticancer activity. |
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V81348 | S6K2-IN-1 | S6K2-IN-1 (Compound 2) is an S6K2 inhibitor (IC50= 22 nM). | |
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V69456 | SNIPER(TACC3)-11 | 2906151-68-4 | SNIPER(TACC3)-11 is a potent inhibitor of fibroblast growth factor receptor 3-transforming acidic coiled-coil 3 (FGFR3-TACC3). |
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V0620 | SSR128129E (SSR 128129E; SSR128129 E) | 848318-25-2 | SSR128129E (also known as SSR-128129E; SSR 128129 E)is a novel, potent,orally bioavailable and allosteric FGFR1 inhibitor with potential anticancer and anti-inflammatory activity. |
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V3982 | SUN11602 | 704869-38-5 | SUN11602 (SUN-11602), a novel synthetic aniline compound with basic fibroblast growth factor-like activity, can mimic the neuroprotective mechanisms of basic fibroblast growth factor. |
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V83228 | Umedaptanib pegol | Umedaptanib pegol is an anti-fibroblast growth factor-2 (FGF2) aptamer | |
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V69480 | Vofatamab (B-701; MFGR-1877S; RG-7444) | 1312305-12-6 | Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). |
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V76353 | Vosoritide acetate (BMN 111 acetate) | Vosoritide (BMN 111) acetate is a natriuretic peptide receptor 2 (NPR2) agonist that acts on chondrocyte proliferation and differentiation to promote bone growth. | |
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V69481 | VSPPLTLGQLLS | 1206896-24-3 | VSPPLTLGQLLS is a small peptide FGFR3 inhibitor, a peptide P3, which can inhibit the phosphorylation of FGFR3. |
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V81748 | VSPPLTLGQLLS TFA | VSPPLTLGQLLS TFA is a small peptide FGFR3 inhibitor, a peptide P3, which can inhibit the phosphorylation of FGFR3. |
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