Trk receptor

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

+MORE

Trk receptor

Trk receptors are a family of three receptor tyrosine kinases (TrkA, TrkB, and TrkC), each of which can be activated by one or more of the four neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4).

The TRK receptor family is made up of the transmembrane proteins TrkA, TrkB, and TrkC. These receptor tyrosine kinases are expressed in human neuronal tissue and are crucial for the physiology of nervous system development and function. Neurotrophins (NTs) activate these receptor tyrosine kinases. For TrkA, BDGF, NT-4/5, and TrkB and TrkC, respectively, these latter substances are specific ligands known as NGF and NT-3.

When a ligand binds to a receptor, the receptors begin to oligomerize and certain tyrosine residues in the intracytoplasmic kinase domain become phosphorylated. As a result of this action, signal transduction pathways that promote proliferation, differentiation, and survival in both healthy and malignant neuronal cells are activated.

Trk receptor related products

Cat No.	Product Name	CAS No.	Product Description
V69602	(3aR)-Selitrectinib ((3aR)-LOXO-195)	1350884-56-8	(3aR)-Selitrectinib ((3aR)-LOXO-195) is an isomer of Selitrectinib.
V78306	1D228		1D228 is a c-Met/TRK inhibitor (antagonist) with anti-tumor activity.
V69587	2-Bromo-6-methoxynaphthalene	5111-65-9	2-Bromo-6-methoxynaphthalene is an active intermediate in the production of anti-inflammatory agents such as Naproxen and Nabumetone via the Heck reaction.
V69583	Amitriptyline-d3 hydrochloride	342611-00-1	Amitriptyline-d3 HCl is the deuterated form of Amitriptyline ( HCl).
V69600	Amitriptyline-d6 hydrochloride (amitriptyline d6 hydrochloride)	203645-63-0	Amitriptyline-d6 ( HCl) is the deuterated form of Amitriptyline HCl.
V0642	ANA-12	219766-25-3	ANA-12 (ANA12) is a novel, potent and selective TrkB inhibitor/antagonist with important biological activity.
V69592	Anizatrectinib (hTrkA-IN-1)	1824664-89-2	Anizatrectinib (hTrkA-IN-1) is a potent oral TrkA kinase inhibitor (antagonist) with IC50 of 1.3 nM, compound 2.
V98056	AZD6918	905585-60-6	AZD6918 is an orally active, selective Trk tyrosine kinase inhibitor.
V85019	CG428	2412055-93-5
V4146	CH7057288	2095616-82-1	CH7057288 is a novel, potent and selectiveinhibitor of TRK (tyrosine receptor kinase) with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively.
V69581	Cyclotraxin B	1203586-72-4	Cyclotraxin B is a cyclic peptide that is a potent and specific TrkB inhibitor (antagonist) without altering BDNF binding.
V78959	Cyclotraxin B TFA		Cyclotraxin B TFA is a cyclic peptide that is a potent and specific TrkB inhibitor (antagonist) without altering BDNF binding.
V69601	ENT-C225	2919962-53-9	ENT-C225 is a potent activator of the TrkB neurotrophin receptor.
V85257	Gambogic amide	286935-60-2
V0641	GNF-5837	1033769-28-6	GNF-5837 (GNF5837) is an orally bioavailable pan-TRK (TrkA, TrkB)inhibitor with potential antitumor activity.
V69586	GNF-8625 monopyridin-N-piperazine hydrochloride	2412055-62-8	GNF-8625 monopyridin-N-piperazine HCl (TRKi-2) is an inhibitor (blocker/antagonist) of TRK, information is from patent WO 2020038415 A1.
V0640	GW441756	504433-23-2	GW441756 (GW-441756) is a novel, potent and selective inhibitor of TrkA (Tropomyosin-related kinase A) with potential anticancer activity.
V98080	HS-345	1462329-41-4	HS-345 is a TrkA/Akt inhibitor with significant anti-pancreatic cancer effects.
V87856	IGF-1R modulator 1	2375424-89-6	IGF-1R modulator 1 (Example 5) is an IGF-1R modulator with EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB).
V30834	LM22B-10	342777-54-2	LM22B-10 (LM22B10) is a novel, potent activator of TrkB/TrkC (Tropomyosin-receptor kinase) neurotrophin receptor, inducing TrkB, TrkC, AKT and ERK activation in vitro and in vivo.