Aurora Kinase

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Aurora Kinase

The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C).Aurora kinases regulate a variety of cell cycle-related processes and are necessary for the assembly and operation of the bipolar spindle during the mitotic and meiotic phases.

While Aurora-A, Aurora-B, and Aurora-C have very similar subcellular localizations and functions during mitosis, they also share a highly conserved kinase domain. While Aurora-B and Aurora-C are necessary for condensation, attachment to kinetochores, and alignment of chromosomes during (pro-)metaphase and cytokinesis, Aurora-A primarily regulates centrosome maturation and bipolar spindle assembly. All Aurora kinase members play oncogenic roles related to their mitotic activity and support the survival and growth of cancer cells in human tumors. Researchers studying cancer have become interested in inhibitors that target Aurora kinases.

Aurora Kinase related products

Cat No.	Product Name	CAS No.	Product Description
V94934	Cenisertib benzoate	1145859-64-8	Cenisertib (AS-703569) benzoate is an ATP-competitive multikinase inhibitor that inhibits the activities of Aurora-kinase-A/B, ABL1, AKT, STAT5, and FLT3.
V88589	DBPR728	2702965-64-6	DBPR728 is an acyl prodrug of 6K465 that carries fewer hydrogen bond donors.
V104462	FAK-IN-22	2703920-02-7	FAK-IN-22 (Compound 26) is an inhibitor of FAK, JAK3, and Aurora B with IC50 values of 50.94 nM, 9.99 nM, and 0.49 nM, respectively, and can effectively inhibit the tumorigenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC).
V84552	FAK/aurora kinase-IN-1	2178117-69-4
V103749	GW814408X	886599-05-9	GW814408X is a kinase chemical genetic group (KCGS) compound that inhibits AURKC kinases involved in cell cycle progression, checkpoint regulation, and cell division.
V51923	JB170	2705844-82-0	JB170 is a potent and specific PROTAC-mediated degrader of AURORA-A (DC50=28 nM) formed by linking Alisertib to the Cereblon ligand Thalidomide.
V94222	MLN8054 sodium	869366-15-4	MLN8054 sodium is an Aurora A inhibitor with radiosensitizing effects.
V4347	Phthalazinone pyrazole	880487-62-7	Phthalazinone pyrazole is a potent, selective, orally bioactive Aurora-Kinase inhibitor (antagonist) with IC50 of 0.031 μM.
V94063	PROTAC MPS1 degrader 1		PROTAC MPS1 degrader 1 (compound 19) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 of 17.7, 108.7, and 570.3 nM, respectively.
V94065	PROTAC MPS1 degrader 2		PROTAC MPS1 degrader 2 (compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 of 42.0, 2.1, and 154.0 nM, respectively.
V4666	SCH-1473759	1094069-99-4	SCH-1473759 (SCH1473759) is a novel, potent and selective aurora inhibitor with anticancer effects.
V35264	SP-96	2682114-54-9	SP-96 is a specific and ATP-competitive Aurora B inhibitor (antagonist) with IC50 of 0.316 nM and >2000-fold selectivity for FLT3 and KIT.
V88593	TAK-901 hydrochloride	934542-50-4	TAK-901 hydrochloride is a multi-target aurora kinase inhibitor with IC50 values of 21 and 15 nM for aurora kinase A and B, respectively.
V55050	Tenacienin B	80508-42-5	Tenacigenin B is a steroid extracted from Alocasia.
V55051	Tinengotinib (TT 00420)	2230490-29-4	Tinengotinib is a modulator of one or more protein kinases, such as Aurora kinase and VEGFR kinase.
V35166	Tripolin A ((E)-Tripolin A)	1148118-92-6	Tripolin A ((E)-Tripolin A) is a specific, non-ATP competitive Aurora A kinase inhibitor (antagonist) with IC50s of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively.
V88596	Tripolin B	186611-44-9	Tripolin B is an ATP-competitive Aurora kinase inhibitor with IC50 values of 2.5 µM and 6 µM for Aurora A and Aurora B kinases, respectively.
V98046	TY-011	1389439-77-3	TY-011 is an Aurora A/B kinase inhibitor.
V73175	YM-08	812647-88-4	YM-08 (Compounds 7a) is an inhibitor (blocker/antagonist) of SIRT2 that can penetrate the BBB (blood-brain barrier), with IC50 of 19.9 μM.
V4411	Ilorasertib	1227939-82-3	Ilorasertib (also known as ABT-348) is a potent, novel, orally bioavailable and ATP-competitive multi-kinase inhibitor withIC50s for inhibiting binding Aurora B (7 nM), C (1 nM), and A (120 nM), and also inhibits RET tyrosine kinase, PDGFRβ, and Flt1 withIC50s of 7 nM, 3 nM and 32 nM.