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CDK

CDK

CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle.Additionally, they control mRNA processing, transcription, and nerve cell differentiation. With molecular weights between 34 and 40 kDa, CDKs are relatively small proteins that only contain the kinase domain. In fact, when their CDK gene has been replaced with the homologous human gene, yeast cells can proliferate normally. A CDK by definition binds the control protein cyclin. Only the cyclin-CDK complex is an active kinase; CDK lacks much kinase activity on its own.

Around 20 Cyclin-dependent kinases (CDK1-20) have been identified as of yet. While CDK 7, 8, 9 and 11 are linked to transcription, CDK1, 4, and 5 are involved in the cell cycle.

The majority of CDK regulation occurs post-translationally, and CDK levels are essentially constant throughout the cell cycle. The majority of knowledge about CDK structure and function is based on CDKs from vertebrates (CDC2 and CDK2), S. pombe (CDC28), and S. cerevisiae (Cdc2). Cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and CDK inhibitory subunit (CKI) binding are the four main mechanisms of CDK regulation.

CDK related products

Structure Cat No. Product Name CAS No. Product Description
CDK9-IN-12 V55096 CDK9-IN-12 1942843-54-0 CDK9-IN-12 showed the best CDK9 inhibitory activity with IC50 of 5.41 nM.
CDK9-IN-13 V75984 CDK9-IN-13 2768712-71-4 CDK9-IN-13 (compound 38) is a potent and specific CDK inhibitor (antagonist) with IC50 <3 nM.
CDK9-IN-22 V52268 CDK9-IN-22 2872677-61-5 CDK9-IN-22 is a potent CDK9 inhibitor (antagonist) with IC50s of 10.4 and 876.2 nM for CDK9 and CDK, respectively.
CDK9-IN-23 V55087 CDK9-IN-23 2761572-96-5 CDK9-IN-23 (Example 4) is a CDK9 inhibitor (antagonist) with IC50 <20 nM.
CDK9-IN-24 V78623 CDK9-IN-24 CDK9-IN-24 (compound 21a) is a selective CDK9 inhibitor (antagonist) with significant inhibitory effect on tumor growth.
CDK9-IN-26 V80215 CDK9-IN-26 CDK9-IN-26 (compound 1d) is a CDK9 inhibitor (IC50=0.18 μM).
CDK9-IN-27 V78705 CDK9-IN-27 CDK9-IN-27 (Compound 6a) is a CDK9 inhibitor (IC50s: 0.424 μM).
CDK9-IN-28 V78706 CDK9-IN-28 CDK9-IN-28 (compound 10) is a potent CDK9 inhibitor.
CDK9-IN-29 V75977 CDK9-IN-29 2737262-24-5 CDK9-IN-29 is a potent CDK9 inhibitor (IC50 = 3.20 nM) with good kinase selectivity.
CDK9-IN-30 V75983 CDK9-IN-30 748146-89-6 CDK9-IN-30 is a CDK9 inhibitor that can suppress the replication of HIV-1 virus.
CDK9-IN-31 V85741 CDK9-IN-31 2991074-93-0
CDK9-IN-31 dimaleate V85719 CDK9-IN-31 dimaleate
CDK9-PROTAC V3574 CDK9-PROTAC 2118356-96-8 CDK9-PROTAC (PROTAC CDK9 Degrader-1) is a novel, potent and selective CDK9(Cyclin-dependent kinase 9) degrader.
CDKI-73 V8118 CDKI-73 1421693-22-2 CDKI-73 is a novel and potent CDK9 inhibitor with Ki of 4 nM.
Cimpuciclib V52250 Cimpuciclib 2202767-78-8 Cimpuciclib is a selective CDK4 inhibitor (IC50= 0.49 nM) with anti-tumor activity.
Cirtuvivint (SM08502) V52248 Cirtuvivint (SM08502) 2143917-62-6 Cirtuvivint (SM08502) is a potent orally bioactive CDC-like kinase (CLK) inhibitor for solid tumor research.
CK7 V52984 CK7 507487-89-0 CK7, a Cdk2/9 inhibitor, may be utilized to prepare the Nek1 inhibitors BSc5231 and BSc5367.
CKI-7 2HCl V5054 CKI-7 2HCl 1177141-67-1 CKI-7 2HCl is a novel, potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM.
CLK-IN-T3 V4769 CLK-IN-T3 2109805-56-1 CLK-IN-T3 is a novel, potent and highly selective CLK (CDC-like kinase)inhibitor with high specificity to CLK1-3 protein isoforms and with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively.
CLK-IN-T3N V75981 CLK-IN-T3N 2561494-73-1 CLK-IN-T3N is the negative control (NC) of CLK-IN-T3, a probe for CLK.
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