Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation.These proteins offer regulatory mechanisms for translation initiation as well as aid in stabilizing the formation of the functional ribosome around the start codon.
A guanine nucleotide-exchange protein called eukaryotic initiation factor 2B (eIF2B) facilitates the conversion of GDP (bound to eIF2) into GTP, thereby regenerating the active [eIF2.GTP] complex necessary for peptide chain initiation. An important regulator of eukaryotic protein synthesis, eIF2B activity changes in response to viral infection, hormones, nutrients, growth factors, and specific stresses.
The role of eukaryotic translation initiation factor 4E (eIF4E) in the beginning of protein synthesis on capped mRNAs in the cytoplasm is well known. The initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome, is composed of the eukaryotic initiation factor (elF) 4A as a subunit.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V55224 | eIF4A3-IN-5 | 2100145-31-9 | eIF4A3-IN-5 is a potent inhibitor of eukaryotic initiation factor 4A (eIF4A), such as eIF4AI and eIF4AII. |
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V55221 | eIF4A3-IN-6 | 2100133-77-3 | eIF4A3-IN-6 is a potent inhibitor of eukaryotic initiation factor 4A (eIF4A), such as eIF4AI and eIF4AII. |
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V55222 | eIF4A3-IN-7 | 2374759-82-5 | eIF4A3-IN-7 is a potent eIF4A3 inhibitor. |
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V55212 | eIF4A3-IN-9 | 1402931-71-8 | eIF4A3-IN-9 (compound 57) is an analog of silvestrol. |
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V51730 | eIF4E-IN-1 | 2573979-31-2 | eIF4E-IN-1 is a potent eIF4E inhibitor. |
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V55223 | eIF4E-IN-2 | 2575840-38-7 | eIF4E-IN-2 is a potent inhibitor of eukaryotic initiation factor 4e (eIF4e). |
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V55213 | eIF4E-IN-3 | 2573979-29-8 | eIF4E-IN-3 is a potent inhibitor of eukaryotic initiation factor 4e (eIF4e). |
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V79274 | eIF4E-IN-5 | eIF4E-IN-5 (Compound 6n) is a cell-penetrating/penetrable inhibitor of eIF4E. | |
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V83938 | GCN2 modulator-1 | 2803470-63-3 | |
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V34703 | GCN2-IN-6 | 2183470-09-7 | GCN2-IN-6 (Compound 6d) is a potent oral GCN2 inhibitor confirmed by enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9.3 nM). |
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V31579 | GCN2iB | 2183470-12-2 | GCN2iB is a novel, potent and ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2) with an IC50 of 2.4 nM. |
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V41046 | ISRIB (mixed cis- and trans-isomer) | 548470-11-7 | ISRIB (mixed cis- and trans-isomer) is a novel and potent ISR (Integrated Stress Response) Inhibitor. |
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V88664 | MNK1/2-IN-7 | 2548283-27-6 | MNK1/2-IN-7 (compound 20j) is an orally available MNK1/2 inhibitor with anticancer activity and hERG safety. |
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V98035 | SBI-0640726 | 1321827-45-5 | SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity against melanoma. |
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V37649 | Didesmethylrocaglamide | 177262-30-5 | Didesmethylrocaglamide is a naturally occurring rocaglamide type of 1H-cyclopenta[b]benzofuran lignans isolated from three Aglaia species (Aglaia duperreana, A. oligophylla and A. spectabilis). |
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V2815 | Briciclib (ON-014185) | 865783-99-9 | Briciclib (also known as ON 013105; ON 014185) is an orally bioavailable small molecule and a disodium phosphate ester prodrug of ON 013100 with improved water solubility compared to ON 013100. |
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