HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on ahistone, allowing the histones to wrap the DNA more tightly.This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V85318 | HDAC6-IN-30 | ||
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V84675 | HDAC6-IN-31 | ||
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V50906 | HDAC8 PROTAC degrader 1 | HDAC8 PROTAC degrader 1 is a HDAC8 PROTAC degrader. | |
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V25196 | HDAC8-IN-1 | 1417997-93-3 | HDAC8-IN-1 is a novel and potent HDAC8 inhibitor with an IC50 of 27.2 nM. |
|
V84650 | HDAC8-IN-6 | ||
|
V51712 | IDO1 and HDAC1 Inhibitor | 2227044-16-6 | IDO1 and HDAC1 Inhibitor is a novel dual inhibitor of HDAC1 and IDO1, with IC50 values of 66.5 nM and 69.0 nM, respectively. |
|
V50953 | ITF-3985 | ITF-3985 HDAC6 is a novel HDAC6 inhibitor. | |
|
V85807 | Martinostat hydrochloride | ||
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V85810 | PB118 | ||
|
V27646 | Pivanex | 122110-53-6 | Pivanex (AN-9; AN 9; AN9; pivaloyloxymethyl butyrate; Titan) is a novel and potent histone deacetylase/HDAC inhibitor with anticancer and antiangiogenic properties. |
|
V3761 | Remetinostat | 946150-57-8 | Remetinostat (formerly known as SHP-141) is an inhibitor of histone deacetylase (HDAC) developed by Medivir as a topical application for use in early stage CTCL (Cutaneous T-cell lymphoma). |
|
V3846 | Resminostat HCl | 1187075-34-8 | Resminostat HCl (formerly known as RAS-2410; RAS2410 and 4SC-201), the hydrochloride salt of Resminostat, is a potent inhibitor of HDAC (histone deacetylase) classes I and II (including HDAC1/3/6) with anticancer activity. |
|
V4636 | SW-100 | 2126744-35-0 | SW-100 (SW100),a tetrahydroquinoline-based compound, is a novel, potent, brain penetrant and selectivehistone deacetylase 6 (HDAC6)inhibitor (IC50 = 2.3 nM) with neuroprotective effects. |
|
V4083 | TH34 | 2196203-96-8 | TH34 is a novel, potent and selective HDAC6/8/10 (histone deacetylase) inhibitor for neuroblastoma therapy. |
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V4087 | UF010 | 537672-41-6 | UF010 (UF-010; UF 010) is a novel, potent and selective class I HDAC inhibitor with potential anticancer activities. |
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V2824 | WT161 | 1206731-57-8 | WT-161 (WT161) is a potent, selective and orally bioavailable HDAC6 inhibitor with IC50 value of 0.40 nM. |
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V85754 | YPX-C-05 | 2894823-79-9 | |
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V85284 | YSR734 | 3032969-58-4 |
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